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- W3005616201 endingPage "144418" @default.
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- W3005616201 abstract "Dopamine beta-hydroxylase (DβH) plays a key role in the synthesis of catecholamines (CAs) in the neuroendocrine regulatory network. The DβH gene was identified from the razor clam Sinonovacula constricta and referred to as ScDβH. The ScDβH gene is a copper type II ascorbate-dependent monooxygenase with a DOMON domain and two Cu2_monooxygen domains. ScDβH transcript expression was abundant in liver and hemolymph. During early development, ScDβH expression significantly increased at the umbo larval stage. Furthermore, the inhibitors and siRNA of DβH were screened. After challenge with DβH inhibitor, the larval metamorphosis and survival rates, and juvenile growth were obviously decreased. Under the siRNA stress, the larval metamorphosis and survival rates were also significantly decreased. Therefore, ScDβH may play an important regulating role in larval metamorphosis and juvenile growth." @default.
- W3005616201 created "2020-02-24" @default.
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- W3005616201 date "2020-05-01" @default.
- W3005616201 modified "2023-09-26" @default.
- W3005616201 title "Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta" @default.
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- W3005616201 doi "https://doi.org/10.1016/j.gene.2020.144418" @default.
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