Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005619707> ?p ?o ?g. }
- W3005619707 abstract "Abstract HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogenesis. We identify four de novo mutational signatures, one of which matches the COSMIC APOBEC-associated signature 2. The viral genomes of the precancer/cancer cases are less likely to contain within-host somatic HPV16 APOBEC3-induced mutations (Fisher’s exact test, P = 6.2 x 10 −14 ), and have a 30% lower nonsynonymous APOBEC3 mutation burden compared to controls. We replicate the low prevalence of HPV16 APOBEC3-induced mutations in 1,749 additional cases. APOBEC3 mutations also historically contribute to the evolution of HPV16 lineages. We demonstrate that cervical infections with a greater burden of somatic HPV16 APOBEC3-induced mutations are more likely to be benign or subsequently clear, suggesting they may reduce persistence, and thus progression, within the host." @default.
- W3005619707 created "2020-02-24" @default.
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- W3005619707 date "2020-02-14" @default.
- W3005619707 modified "2023-10-18" @default.
- W3005619707 title "Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance" @default.
- W3005619707 cites W1644482461 @default.
- W3005619707 cites W1842792112 @default.
- W3005619707 cites W1964783528 @default.
- W3005619707 cites W1966343819 @default.
- W3005619707 cites W1966905366 @default.
- W3005619707 cites W1977012657 @default.
- W3005619707 cites W1977942351 @default.
- W3005619707 cites W1980636777 @default.
- W3005619707 cites W1984669473 @default.
- W3005619707 cites W1986241711 @default.
- W3005619707 cites W1987350137 @default.
- W3005619707 cites W1994245391 @default.
- W3005619707 cites W1997345818 @default.
- W3005619707 cites W1999207703 @default.
- W3005619707 cites W2003665515 @default.
- W3005619707 cites W2004805218 @default.
- W3005619707 cites W2008255210 @default.
- W3005619707 cites W2008684414 @default.
- W3005619707 cites W2008811015 @default.
- W3005619707 cites W2009933647 @default.
- W3005619707 cites W2017928122 @default.
- W3005619707 cites W2020386919 @default.
- W3005619707 cites W2026598187 @default.
- W3005619707 cites W2034471415 @default.
- W3005619707 cites W2044563319 @default.
- W3005619707 cites W2065150919 @default.
- W3005619707 cites W2066400897 @default.
- W3005619707 cites W2068965703 @default.
- W3005619707 cites W2072155047 @default.
- W3005619707 cites W2077247484 @default.
- W3005619707 cites W2087136946 @default.
- W3005619707 cites W2090870297 @default.
- W3005619707 cites W2094413487 @default.
- W3005619707 cites W2096733107 @default.
- W3005619707 cites W2101196984 @default.
- W3005619707 cites W2101758659 @default.
- W3005619707 cites W2102536992 @default.
- W3005619707 cites W2104153021 @default.
- W3005619707 cites W2106578986 @default.
- W3005619707 cites W2108124592 @default.
- W3005619707 cites W2108506470 @default.
- W3005619707 cites W2117969937 @default.
- W3005619707 cites W2129136620 @default.
- W3005619707 cites W2131255017 @default.
- W3005619707 cites W2132384241 @default.
- W3005619707 cites W2136111158 @default.
- W3005619707 cites W2136304428 @default.
- W3005619707 cites W2137051059 @default.
- W3005619707 cites W2139736159 @default.
- W3005619707 cites W2141272547 @default.
- W3005619707 cites W2148287035 @default.
- W3005619707 cites W2149866054 @default.
- W3005619707 cites W2152061559 @default.
- W3005619707 cites W2153866279 @default.
- W3005619707 cites W2159416556 @default.
- W3005619707 cites W2160472688 @default.
- W3005619707 cites W2167639680 @default.
- W3005619707 cites W2168422160 @default.
- W3005619707 cites W2168696662 @default.
- W3005619707 cites W2169918603 @default.
- W3005619707 cites W2192486276 @default.
- W3005619707 cites W2204392137 @default.
- W3005619707 cites W2278687548 @default.
- W3005619707 cites W2311203695 @default.
- W3005619707 cites W2344334611 @default.
- W3005619707 cites W2344657883 @default.
- W3005619707 cites W2465456043 @default.
- W3005619707 cites W2517730488 @default.
- W3005619707 cites W2522155417 @default.