FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005648400> ?p ?o ?g. }

• W3005648400 endingPage "242" @default.
• W3005648400 startingPage "235" @default.
• W3005648400 abstract "Abstract Background Scleroderma renal crisis (SRC) is a rare but feared complication with high morbidity and mortality. Its aetiopathogenesis is unclear. Aim To investigate epidemiological, serologic and clinical features of all patients with SRC listed on the population‐based South Australian Scleroderma Register and to examine possible factors in aetiopathogenesis. Method A case note review was performed on all SRC patients with relevant data extracted to determine incidence, clinical phenotype, presence of autoantibodies and survival. Possible precipitating and aetiopathogenic factors were also examined. Data from the South Australian Scleroderma Register and Australia Bureau of Statistics was sourced for comparative purposes. Results Over the 34‐year period (1985–2018), 30 patients (21 females, 9 males) presented with SRC giving a South Australian mean annual incidence of 0.58/million/year (95% CI 0.39–0.89). Twenty‐eight of these patients had diffuse cutaneous scleroderma and two with limited cutaneous scleroderma. The mean age at first symptom of scleroderma was 51.2 ± 15.9 (mean ± SD) years with SRC occurring 4.6 years later (median = 3.0 years, range 0.1–20 years). Possible precipitating factors for SRC included high dose steroids in five patients. Twelve patients were anti‐ RNA polymerase3 (RNAPol3) positive and two were anti‐topoisomerase 1 (Topo1) positive. Renal outcome was poor with 13 patients requiring renal replacement therapy and two proceeding to renal transplantation. The mean age at death was 61.2 ± 11.6 years with SRC patient survival being significantly shorter than patients with diffuse scleroderma without renal involvement ( P = 0.002). There was no significant difference in survival between the 1985–2002 and the 2003–2018 SRC cohorts ( P = 0.2). Nailfold capillaroscopy performed in 10 patients revealed extensive microvascular damage with prominent capillary drop out. Conclusion SRC is a rare occurrence with an incidence of 0.58/million/year in South Australia. This frequency has not changed over time. It continues to have a severe adverse outcome with frequent requirement for renal replacement therapy and poor survival. Nailfold capillaroscopy revealed evidence of extensive capillary damage. No improvement in survival was observed over the 34‐year study period." @default.
• W3005648400 created "2020-02-24" @default.
• W3005648400 creator A5015986936 @default.
• W3005648400 creator A5026779492 @default.
• W3005648400 creator A5034122152 @default.
• W3005648400 creator A5055291003 @default.
• W3005648400 creator A5066790436 @default.
• W3005648400 creator A5066921526 @default.
• W3005648400 creator A5071491252 @default.
• W3005648400 creator A5078271584 @default.
• W3005648400 creator A5086044066 @default.
• W3005648400 date "2021-02-01" @default.
• W3005648400 modified "2023-09-27" @default.
• W3005648400 title "Scleroderma renal crisis: observations from the South Australian Scleroderma Register" @default.
• W3005648400 cites W1538849949 @default.
• W3005648400 cites W1595501421 @default.
• W3005648400 cites W1987038859 @default.
• W3005648400 cites W2057047056 @default.
• W3005648400 cites W2063522157 @default.
• W3005648400 cites W2069856332 @default.
• W3005648400 cites W2086287791 @default.
• W3005648400 cites W2086506381 @default.
• W3005648400 cites W2172106520 @default.
• W3005648400 cites W2344983070 @default.
• W3005648400 cites W2523740842 @default.
• W3005648400 cites W2790348244 @default.
• W3005648400 cites W2908292799 @default.
• W3005648400 cites W2958303219 @default.
• W3005648400 cites W2958609750 @default.
• W3005648400 cites W3171123303 @default.
• W3005648400 doi "https://doi.org/10.1111/imj.14772" @default.
• W3005648400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32043674" @default.
• W3005648400 hasPublicationYear "2021" @default.
• W3005648400 type Work @default.
• W3005648400 sameAs 3005648400 @default.
• W3005648400 citedByCount "2" @default.
• W3005648400 countsByYear W30056484002021 @default.
• W3005648400 crossrefType "journal-article" @default.
• W3005648400 hasAuthorship W3005648400A5015986936 @default.
• W3005648400 hasAuthorship W3005648400A5026779492 @default.
• W3005648400 hasAuthorship W3005648400A5034122152 @default.
• W3005648400 hasAuthorship W3005648400A5055291003 @default.
• W3005648400 hasAuthorship W3005648400A5066790436 @default.
• W3005648400 hasAuthorship W3005648400A5066921526 @default.
• W3005648400 hasAuthorship W3005648400A5071491252 @default.
• W3005648400 hasAuthorship W3005648400A5078271584 @default.
• W3005648400 hasAuthorship W3005648400A5086044066 @default.
• W3005648400 hasConcept C107130276 @default.
• W3005648400 hasConcept C120665830 @default.
• W3005648400 hasConcept C121332964 @default.
• W3005648400 hasConcept C126322002 @default.
• W3005648400 hasConcept C141071460 @default.
• W3005648400 hasConcept C142724271 @default.
• W3005648400 hasConcept C159654299 @default.
• W3005648400 hasConcept C163764329 @default.
• W3005648400 hasConcept C180032290 @default.
• W3005648400 hasConcept C203014093 @default.
• W3005648400 hasConcept C2778751314 @default.
• W3005648400 hasConcept C2779625490 @default.
• W3005648400 hasConcept C2779967694 @default.
• W3005648400 hasConcept C2908647359 @default.
• W3005648400 hasConcept C61511704 @default.
• W3005648400 hasConcept C71924100 @default.
• W3005648400 hasConcept C99454951 @default.
• W3005648400 hasConceptScore W3005648400C107130276 @default.
• W3005648400 hasConceptScore W3005648400C120665830 @default.
• W3005648400 hasConceptScore W3005648400C121332964 @default.
• W3005648400 hasConceptScore W3005648400C126322002 @default.
• W3005648400 hasConceptScore W3005648400C141071460 @default.
• W3005648400 hasConceptScore W3005648400C142724271 @default.
• W3005648400 hasConceptScore W3005648400C159654299 @default.
• W3005648400 hasConceptScore W3005648400C163764329 @default.
• W3005648400 hasConceptScore W3005648400C180032290 @default.
• W3005648400 hasConceptScore W3005648400C203014093 @default.
• W3005648400 hasConceptScore W3005648400C2778751314 @default.
• W3005648400 hasConceptScore W3005648400C2779625490 @default.
• W3005648400 hasConceptScore W3005648400C2779967694 @default.
• W3005648400 hasConceptScore W3005648400C2908647359 @default.
• W3005648400 hasConceptScore W3005648400C61511704 @default.
• W3005648400 hasConceptScore W3005648400C71924100 @default.
• W3005648400 hasConceptScore W3005648400C99454951 @default.
• W3005648400 hasIssue "2" @default.
• W3005648400 hasLocation W30056484001 @default.
• W3005648400 hasOpenAccess W3005648400 @default.
• W3005648400 hasPrimaryLocation W30056484001 @default.
• W3005648400 hasRelatedWork W141491139 @default.
• W3005648400 hasRelatedWork W1595501421 @default.
• W3005648400 hasRelatedWork W1977299683 @default.
• W3005648400 hasRelatedWork W2033970484 @default.
• W3005648400 hasRelatedWork W2039204046 @default.
• W3005648400 hasRelatedWork W2099279533 @default.
• W3005648400 hasRelatedWork W2117750990 @default.
• W3005648400 hasRelatedWork W2161476145 @default.
• W3005648400 hasRelatedWork W2167103565 @default.
• W3005648400 hasRelatedWork W2425879134 @default.
• W3005648400 hasVolume "51" @default.
• W3005648400 isParatext "false" @default.
• W3005648400 isRetracted "false" @default.

• next