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- W3005655607 abstract "Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in vivo. The necessity of these activity bursts for sensorimotor control and their roles in specific phases of movement are unknown. Here we show that temporally-restricted optosilencing of spontaneous or sensory-evoked HON bursts disrupts locomotion initiation, but does not affect ongoing locomotion. Conversely, HON optostimulation initiates locomotion with subsecond delays in a frequency-dependent manner. Using 2-photon volumetric imaging of activity of >300 HONs during sensory stimulation and self-initiated locomotion, we identify several locomotion-related HON subtypes, which distinctly predict the probability of imminent locomotion initiation, display distinct sensory responses, and are differentially modulated by food deprivation. By causally linking HON bursts to locomotion initiation, these findings reveal the sensorimotor importance of rapid spontaneous and evoked fluctuations in HON ensemble activity." @default.
- W3005655607 created "2020-02-24" @default.
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- W3005655607 date "2020-04-01" @default.
- W3005655607 modified "2023-09-27" @default.
- W3005655607 title "Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation" @default.
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- W3005655607 doi "https://doi.org/10.1016/j.pneurobio.2020.101771" @default.
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