FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005661908> ?p ?o ?g. }

• W3005661908 endingPage "1356" @default.
• W3005661908 startingPage "1348" @default.
• W3005661908 abstract "Membrane durability is critical for regenerative procedures. We reported previously that type 1-like diabetes in rats accelerates the degradation of collagen membranes and we tested here whether this is associated with increased local production of inflammatory molecules as part of a diabetes-induced chronic inflammation around and within the membranes.Collagen membrane discs were implanted under the scalp in diabetic (streptozotocin-induced) and control rats, which were sacrificed after 2 or 3 weeks. Total RNA and proteins were isolated from the membrane and its surrounding tissues and the expression and production of six inflammatory molecules (interleukin-6 [IL-6], tumor necrosis factor alpha [TNFα], matrix metalloproteinase [MMP]-9, macrophage migration inhibitory factor [MIF], MIP-1α, and MIP-2α) was measured using real-time PCR and western blotting, respectively. Minimal histological analysis of the membranes was conducted to conform to previous studies.Hyperglycemia resulted in reduced membrane thickness (by 10% to 25%) and increased mononuclear infiltrate inside the membrane. mRNA and protein levels of IL-6, TNFα, and MMP-9 were elevated in diabetic rats both 2 and 3 weeks post-surgery. The levels (both mRNA and protein) of MIF were increased at 2 weeks post-surgery and those of MIP-1α and MIP-2α at 3 weeks. There was a very good match in the temporal changes of all examined genes between the mRNA and protein levels.Elevated local production of inflammatory cytokines and MMPs, together with apparent mononuclear infiltrate and increased collagenolysis confirm that hyperglycemia leads to a chronic inflammation in and around the implanted collagen membranes, which reduces membrane longevity." @default.
• W3005661908 created "2020-02-24" @default.
• W3005661908 creator A5004194704 @default.
• W3005661908 creator A5043851741 @default.
• W3005661908 creator A5056376223 @default.
• W3005661908 creator A5075804395 @default.
• W3005661908 creator A5091764442 @default.
• W3005661908 date "2020-03-06" @default.
• W3005661908 modified "2023-10-01" @default.
• W3005661908 title "Accelerated degradation of collagen membranes in type 1 diabetic rats is associated with increased expression and production of several inflammatory molecules" @default.
• W3005661908 cites W1524578276 @default.
• W3005661908 cites W155367197 @default.
• W3005661908 cites W1621491352 @default.
• W3005661908 cites W1846701731 @default.
• W3005661908 cites W1872082610 @default.
• W3005661908 cites W1977351619 @default.
• W3005661908 cites W1989832114 @default.
• W3005661908 cites W1995504887 @default.
• W3005661908 cites W2004337957 @default.
• W3005661908 cites W2004462908 @default.
• W3005661908 cites W2016813609 @default.
• W3005661908 cites W2020857695 @default.
• W3005661908 cites W2040429983 @default.
• W3005661908 cites W2045362322 @default.
• W3005661908 cites W2046927738 @default.
• W3005661908 cites W2060915732 @default.
• W3005661908 cites W2064119981 @default.
• W3005661908 cites W2087187911 @default.
• W3005661908 cites W2088810004 @default.
• W3005661908 cites W2090475821 @default.
• W3005661908 cites W2101926861 @default.
• W3005661908 cites W2108192985 @default.
• W3005661908 cites W2130892977 @default.
• W3005661908 cites W2135157677 @default.
• W3005661908 cites W2163670330 @default.
• W3005661908 cites W2288659702 @default.
• W3005661908 cites W2339057154 @default.
• W3005661908 cites W2517441209 @default.
• W3005661908 cites W2522659753 @default.
• W3005661908 cites W2570966546 @default.
• W3005661908 cites W2610585610 @default.
• W3005661908 cites W2626447691 @default.
• W3005661908 cites W2749653140 @default.
• W3005661908 cites W2751828697 @default.
• W3005661908 cites W2766914792 @default.
• W3005661908 cites W2790116576 @default.
• W3005661908 cites W2792446562 @default.
• W3005661908 cites W2890761540 @default.
• W3005661908 cites W2891326528 @default.
• W3005661908 cites W2896169315 @default.
• W3005661908 cites W2897377556 @default.
• W3005661908 cites W2912619585 @default.
• W3005661908 cites W2938200783 @default.
• W3005661908 cites W2941259798 @default.
• W3005661908 cites W2951331185 @default.
• W3005661908 cites W4241883936 @default.
• W3005661908 doi "https://doi.org/10.1002/jper.19-0503" @default.
• W3005661908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32056217" @default.
• W3005661908 hasPublicationYear "2020" @default.
• W3005661908 type Work @default.
• W3005661908 sameAs 3005661908 @default.
• W3005661908 citedByCount "3" @default.
• W3005661908 countsByYear W30056619082021 @default.
• W3005661908 countsByYear W30056619082023 @default.
• W3005661908 crossrefType "journal-article" @default.
• W3005661908 hasAuthorship W3005661908A5004194704 @default.
• W3005661908 hasAuthorship W3005661908A5043851741 @default.
• W3005661908 hasAuthorship W3005661908A5056376223 @default.
• W3005661908 hasAuthorship W3005661908A5075804395 @default.
• W3005661908 hasAuthorship W3005661908A5091764442 @default.
• W3005661908 hasConcept C104317684 @default.
• W3005661908 hasConcept C105580179 @default.
• W3005661908 hasConcept C109523444 @default.
• W3005661908 hasConcept C126322002 @default.
• W3005661908 hasConcept C134018914 @default.
• W3005661908 hasConcept C137061746 @default.
• W3005661908 hasConcept C164027704 @default.
• W3005661908 hasConcept C17991360 @default.
• W3005661908 hasConcept C185592680 @default.
• W3005661908 hasConcept C202751555 @default.
• W3005661908 hasConcept C2776914184 @default.
• W3005661908 hasConcept C2779280383 @default.
• W3005661908 hasConcept C41625074 @default.
• W3005661908 hasConcept C55493867 @default.
• W3005661908 hasConcept C555293320 @default.
• W3005661908 hasConcept C71924100 @default.
• W3005661908 hasConcept C85265743 @default.
• W3005661908 hasConceptScore W3005661908C104317684 @default.
• W3005661908 hasConceptScore W3005661908C105580179 @default.
• W3005661908 hasConceptScore W3005661908C109523444 @default.
• W3005661908 hasConceptScore W3005661908C126322002 @default.
• W3005661908 hasConceptScore W3005661908C134018914 @default.
• W3005661908 hasConceptScore W3005661908C137061746 @default.
• W3005661908 hasConceptScore W3005661908C164027704 @default.
• W3005661908 hasConceptScore W3005661908C17991360 @default.
• W3005661908 hasConceptScore W3005661908C185592680 @default.
• W3005661908 hasConceptScore W3005661908C202751555 @default.
• W3005661908 hasConceptScore W3005661908C2776914184 @default.

• next