FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005667035> ?p ?o ?g. }

• W3005667035 endingPage "100963" @default.
• W3005667035 startingPage "100963" @default.
• W3005667035 abstract "Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms remain largely unknown. In this study we sought to determine the translatomic signatures associated with pro-opiomelanocortin (POMC) neuron malprogramming in maternal obesogenic conditions. We used the RiboTag mouse model to specifically profile the translatome of POMC neurons during neonatal (P0) and perinatal (P21) life and its neuroanatomical, functional, and physiological consequences. Maternal high-fat diet (HFD) exposure did not interfere with offspring's hypothalamic POMC neuron specification, but significantly impaired their spatial distribution and axonal extension to target areas. Importantly, we established POMC neuron-specific translatome signatures accounting for aberrant neuronal development and axonal growth. These anatomical and molecular alterations caused metabolic dysfunction in early life and adulthood. Our study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts." @default.
• W3005667035 created "2020-02-24" @default.
• W3005667035 creator A5007797779 @default.
• W3005667035 creator A5009750098 @default.
• W3005667035 creator A5009790595 @default.
• W3005667035 creator A5015912176 @default.
• W3005667035 creator A5020468723 @default.
• W3005667035 creator A5026726668 @default.
• W3005667035 creator A5032287316 @default.
• W3005667035 creator A5049044746 @default.
• W3005667035 creator A5056209287 @default.
• W3005667035 creator A5069614527 @default.
• W3005667035 creator A5075223565 @default.
• W3005667035 creator A5085543570 @default.
• W3005667035 date "2020-06-01" @default.
• W3005667035 modified "2023-10-12" @default.
• W3005667035 title "Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice" @default.
• W3005667035 cites W1972275518 @default.
• W3005667035 cites W1973094248 @default.
• W3005667035 cites W1974558371 @default.
• W3005667035 cites W1987922392 @default.
• W3005667035 cites W1991768027 @default.
• W3005667035 cites W1992423721 @default.
• W3005667035 cites W1993598672 @default.
• W3005667035 cites W2003238068 @default.
• W3005667035 cites W2009128626 @default.
• W3005667035 cites W2074225842 @default.
• W3005667035 cites W2075480833 @default.
• W3005667035 cites W2092223956 @default.
• W3005667035 cites W2097065948 @default.
• W3005667035 cites W2114104545 @default.
• W3005667035 cites W2117921399 @default.
• W3005667035 cites W2128098876 @default.
• W3005667035 cites W2134526812 @default.
• W3005667035 cites W2141386697 @default.
• W3005667035 cites W2143423915 @default.
• W3005667035 cites W2146152985 @default.
• W3005667035 cites W2159675211 @default.
• W3005667035 cites W2161418574 @default.
• W3005667035 cites W2171030481 @default.
• W3005667035 cites W2342841536 @default.
• W3005667035 cites W2409801806 @default.
• W3005667035 cites W2472629326 @default.
• W3005667035 cites W2586421092 @default.
• W3005667035 cites W2784117084 @default.
• W3005667035 cites W2807050977 @default.
• W3005667035 cites W2897195287 @default.
• W3005667035 cites W2915007177 @default.
• W3005667035 cites W2917520831 @default.
• W3005667035 cites W2950724991 @default.
• W3005667035 cites W2968993257 @default.
• W3005667035 doi "https://doi.org/10.1016/j.molmet.2020.02.006" @default.
• W3005667035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7152705" @default.
• W3005667035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32283518" @default.
• W3005667035 hasPublicationYear "2020" @default.
• W3005667035 type Work @default.
• W3005667035 sameAs 3005667035 @default.
• W3005667035 citedByCount "10" @default.
• W3005667035 countsByYear W30056670352021 @default.
• W3005667035 countsByYear W30056670352022 @default.
• W3005667035 countsByYear W30056670352023 @default.
• W3005667035 crossrefType "journal-article" @default.
• W3005667035 hasAuthorship W3005667035A5007797779 @default.
• W3005667035 hasAuthorship W3005667035A5009750098 @default.
• W3005667035 hasAuthorship W3005667035A5009790595 @default.
• W3005667035 hasAuthorship W3005667035A5015912176 @default.
• W3005667035 hasAuthorship W3005667035A5020468723 @default.
• W3005667035 hasAuthorship W3005667035A5026726668 @default.
• W3005667035 hasAuthorship W3005667035A5032287316 @default.
• W3005667035 hasAuthorship W3005667035A5049044746 @default.
• W3005667035 hasAuthorship W3005667035A5056209287 @default.
• W3005667035 hasAuthorship W3005667035A5069614527 @default.
• W3005667035 hasAuthorship W3005667035A5075223565 @default.
• W3005667035 hasAuthorship W3005667035A5085543570 @default.
• W3005667035 hasBestOaLocation W30056670351 @default.
• W3005667035 hasConcept C112672928 @default.
• W3005667035 hasConcept C126322002 @default.
• W3005667035 hasConcept C134018914 @default.
• W3005667035 hasConcept C169760540 @default.
• W3005667035 hasConcept C2778794669 @default.
• W3005667035 hasConcept C2779234561 @default.
• W3005667035 hasConcept C54355233 @default.
• W3005667035 hasConcept C71924100 @default.
• W3005667035 hasConcept C86803240 @default.
• W3005667035 hasConceptScore W3005667035C112672928 @default.
• W3005667035 hasConceptScore W3005667035C126322002 @default.
• W3005667035 hasConceptScore W3005667035C134018914 @default.
• W3005667035 hasConceptScore W3005667035C169760540 @default.
• W3005667035 hasConceptScore W3005667035C2778794669 @default.
• W3005667035 hasConceptScore W3005667035C2779234561 @default.
• W3005667035 hasConceptScore W3005667035C54355233 @default.
• W3005667035 hasConceptScore W3005667035C71924100 @default.
• W3005667035 hasConceptScore W3005667035C86803240 @default.
• W3005667035 hasFunder F4320321505 @default.
• W3005667035 hasFunder F4320332999 @default.
• W3005667035 hasFunder F4320334923 @default.
• W3005667035 hasFunder F4320335322 @default.
• W3005667035 hasFunder F4320338335 @default.

• next