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- W3005668035 endingPage "7208" @default.
- W3005668035 startingPage "7195" @default.
- W3005668035 abstract "β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 participates in reprogramming tumor metabolism, shaping the stromal and immune microenvironment, facilitating epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (End-MT) and maintaining tumor stemness, etc. Recent studies proposed various intervention strategies against ITGB3 and have achieved promising outcomes in several types of tumor. Here, we review the adaption response and cellular crosstalk in the tumor microenvironment mediated by ITGB3, as well as its upstream and downstream signaling pathways. Lastly, we focus on the inhibitors of ITGB3, ultimately indicating that ITGB3 is a promising target in the tumor microenvironment." @default.
- W3005668035 created "2020-02-24" @default.
- W3005668035 creator A5034311245 @default.
- W3005668035 creator A5036532057 @default.
- W3005668035 creator A5045150831 @default.
- W3005668035 creator A5075523709 @default.
- W3005668035 creator A5078039491 @default.
- W3005668035 creator A5089413821 @default.
- W3005668035 date "2019-01-01" @default.
- W3005668035 modified "2023-10-01" @default.
- W3005668035 title "ITGB3/CD61: a hub modulator and target in the tumor microenvironment." @default.
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