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• W3005707144 startingPage "1337" @default.
• W3005707144 abstract "To assess changes of metabolite content and regulation mechanism of the phenolic acid biosynthesis pathway at different developmental stages of leaves, this study performed a combined metabolome and transcriptome analysis of Cyclocarya paliurus leaves at different developmental stages. Metabolite and transcript profiling were conducted by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometer and high-throughput RNA sequencing, respectively. Transcriptome identification showed that 58 genes were involved in the biosynthesis of phenolic acid. Among them, 10 differentially expressed genes were detected between every two developmental stages. Identification and quantification of metabolites indicated that 14 metabolites were located in the phenolic acid biosynthetic pathway. Among them, eight differentially accumulated metabolites were detected between every two developmental stages. Association analysis between metabolome and transcriptome showed that six differentially expressed structural genes were significantly positively correlated with metabolite accumulation and showed similar expression trends. A total of 128 transcription factors were identified that may be involved in the regulation of phenolic acid biosynthesis; these include 12 MYBs and 10 basic helix–loop–helix (bHLH) transcription factors. A regulatory network of the phenolic acid biosynthesis was established to visualize differentially expressed candidate genes that are involved in the accumulation of metabolites with significant differences. The results of this study contribute to the further understanding of phenolic acid biosynthesis during the development of leaves of C. paliurus." @default.
• W3005707144 created "2020-02-24" @default.
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• W3005707144 date "2020-02-17" @default.
• W3005707144 modified "2023-10-15" @default.
• W3005707144 title "Combined Analysis of the Metabolome and Transcriptome Identified Candidate Genes Involved in Phenolic Acid Biosynthesis in the Leaves of Cyclocarya paliurus" @default.
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• W3005707144 doi "https://doi.org/10.3390/ijms21041337" @default.
• W3005707144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7073005" @default.
• W3005707144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32079236" @default.
• W3005707144 hasPublicationYear "2020" @default.
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