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- W3005772695 abstract "This paper reports a novel redox-sensitive micellar system for the co-delivery of doxorubicin (Dox) and a chemosensitizer (curcumin, Cur) to overcome the multidrug resistance (MDR) in cancer cells. Dox and Cur were co-conjugated onto a zwitterionic polymer, poly(carboxybetaine) (pCB), to form Cur-pCB-Dox that self-assembled into stable micelles (164.2 ± 4.8 nm). Single-drug conjugates (pCB-Dox and pCB-Cur) were prepared for comparisons. Compared to the high half-maximal inhibitory concentration (IC50) of Dox (437.2 μg/mL), the IC50 value of pCB-Dox (14.1 μg/mL) was only 1/33 that of Dox. Confocal laser scanning microscopy and flow cytometry revealed the greatly enhanced cell uptake of the conjugate due to the enhanced permeability and retention effect of tumor cells on the micellar conjugate. Co-delivery of pCB-Dox with pCB-Cur further reduced the IC50 value by 37% (8.9 μg/mL). More importantly, Cur-pCB-Dox exhibited the strongest cytotoxicity against MCF-7/Adr cells (IC50, 5.87 μg/mL) because the co-delivered Dox and Cur on one carrier specifically transported into the same cells, which inhibited the efflux of Dox by Cur, led to a higher intracellular Dox concentration and made the drugs exert synergistic effects at the targeting regions. The results proved the zwitterionic micelles as promising drug co-delivery vehicles for fighting against MDR." @default.
- W3005772695 created "2020-02-24" @default.
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- W3005772695 date "2020-02-10" @default.
- W3005772695 modified "2023-09-30" @default.
- W3005772695 title "Zwitterionic Polymer Micelles with Dual Conjugation of Doxorubicin and Curcumin: Synergistically Enhanced Efficacy against Multidrug-Resistant Tumor Cells" @default.
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- W3005772695 cites W1991611141 @default.
- W3005772695 cites W1992796636 @default.
- W3005772695 cites W1995050500 @default.
- W3005772695 cites W1995690527 @default.
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- W3005772695 cites W2019533416 @default.
- W3005772695 cites W2022834762 @default.
- W3005772695 cites W2025114138 @default.
- W3005772695 cites W2033281188 @default.
- W3005772695 cites W2034520377 @default.
- W3005772695 cites W2035134488 @default.
- W3005772695 cites W2039120979 @default.
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- W3005772695 cites W2075900174 @default.
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- W3005772695 cites W257094742 @default.
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- W3005772695 cites W2594622216 @default.
- W3005772695 cites W2608334856 @default.
- W3005772695 cites W2638953127 @default.
- W3005772695 cites W2726169462 @default.
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- W3005772695 doi "https://doi.org/10.1021/acs.langmuir.9b03722" @default.
- W3005772695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32036662" @default.
- W3005772695 hasPublicationYear "2020" @default.
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