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• W3005773496 endingPage "191338" @default.
• W3005773496 startingPage "191338" @default.
• W3005773496 abstract "Animals fed a Western-style diet (WS-diet) demonstrate rapid impairments in hippocampal function and poorer appetitive control. We examined if this also occurs in humans. One-hundred and ten healthy lean adults were randomized to either a one-week WS-diet intervention or a habitual-diet control group. Measures of hippocampal-dependent learning and memory (HDLM) and of appetitive control were obtained pre- and post-intervention. HDLM was retested at three-week follow-up. Relative to controls, HDLM performance declined in the WS-diet group ( d = 0.43), but was not different at follow-up. Appetitive control also declined in the WS-diet group ( d = 0.47) and this was strongly correlated with HDLM decline ( d = 1.01). These findings demonstrate that a WS-diet can rapidly impair appetitive control in humans—an effect that could promote overeating in consumers of a WS-diet. The study also suggests a functional role for the hippocampus in appetitive control and provides new evidence for the adverse neurocognitive effects of a WS-diet." @default.
• W3005773496 created "2020-02-24" @default.
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• W3005773496 date "2020-02-01" @default.
• W3005773496 modified "2023-10-02" @default.
• W3005773496 title "Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet" @default.
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• W3005773496 doi "https://doi.org/10.1098/rsos.191338" @default.
• W3005773496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7062097" @default.
• W3005773496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32257311" @default.
• W3005773496 hasPublicationYear "2020" @default.
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