Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005782880> ?p ?o ?g. }
- W3005782880 endingPage "279" @default.
- W3005782880 startingPage "269" @default.
- W3005782880 abstract "Summary Monocytic‐lineage cells in the central nervous system (CNS), including microglia and brain resident macrophages, are the key players in the CNS innate immunity against viral infections, including human immunodeficiency virus (HIV). However, these cells also serve as the major targets and reservoirs for HIV in the CNS. To address the question of how HIV can establish persistent infection in the target cells in the CNS, we examined whether HIV has the ability to counteract Toll‐like receptor 3 (TLR3) activation‐mediated antiviral immunity in microglia and macrophages. We observed that HIV latently infected microglial cells (HC69·5) expressed reduced levels of TLR3 and TLR3 activation‐mediated interferons (IFN‐α/β and IFN‐λ) as compared with the uninfected control cells (C20). In addition, HIV infection of primary human macrophages suppressed the expression of TLR3 and the IFNs. HIV infection also inhibited the expression of the antiviral IFN‐stimulated genes (ISGs) and the HIV‐restriction miRNAs. Mechanistically, HIV infection inhibited the phosphorylation of IFN regulatory factors (IRF3 and IRF7) and signal transducer and activator of transcription proteins (STAT1 and STAT3) in both HIV latently infected microglia and acutely infected macrophages. These findings provide previously unrecognized and sound mechanisms for HIV infection and persistence in the primary target and reservoir cells in the brain." @default.
- W3005782880 created "2020-02-24" @default.
- W3005782880 creator A5005042323 @default.
- W3005782880 creator A5010781271 @default.
- W3005782880 creator A5013881064 @default.
- W3005782880 creator A5018389673 @default.
- W3005782880 creator A5024937410 @default.
- W3005782880 creator A5068383527 @default.
- W3005782880 creator A5069715775 @default.
- W3005782880 date "2020-05-03" @default.
- W3005782880 modified "2023-09-27" @default.
- W3005782880 title "HIV infection suppresses TLR3 activation‐mediated antiviral immunity in microglia and macrophages" @default.
- W3005782880 cites W1505585456 @default.
- W3005782880 cites W1511893663 @default.
- W3005782880 cites W1521072910 @default.
- W3005782880 cites W1547593654 @default.
- W3005782880 cites W1623115463 @default.
- W3005782880 cites W1691093350 @default.
- W3005782880 cites W1966060871 @default.
- W3005782880 cites W1986178107 @default.
- W3005782880 cites W1987410025 @default.
- W3005782880 cites W1995744610 @default.
- W3005782880 cites W2002938531 @default.
- W3005782880 cites W2005312649 @default.
- W3005782880 cites W2009230499 @default.
- W3005782880 cites W2010501182 @default.
- W3005782880 cites W2015141049 @default.
- W3005782880 cites W2015415445 @default.
- W3005782880 cites W2026772883 @default.
- W3005782880 cites W2031913105 @default.
- W3005782880 cites W2045807962 @default.
- W3005782880 cites W2049772720 @default.
- W3005782880 cites W2051940924 @default.
- W3005782880 cites W2052097159 @default.
- W3005782880 cites W2059181603 @default.
- W3005782880 cites W2061203855 @default.
- W3005782880 cites W2088312322 @default.
- W3005782880 cites W2089556791 @default.
- W3005782880 cites W2090163159 @default.
- W3005782880 cites W2093318093 @default.
- W3005782880 cites W2093661173 @default.
- W3005782880 cites W2096139318 @default.
- W3005782880 cites W2098038342 @default.
- W3005782880 cites W2102953855 @default.
- W3005782880 cites W2103348038 @default.
- W3005782880 cites W2110525565 @default.
- W3005782880 cites W2121921570 @default.
- W3005782880 cites W2122161932 @default.
- W3005782880 cites W2124473438 @default.
- W3005782880 cites W2124667416 @default.
- W3005782880 cites W2127040944 @default.
- W3005782880 cites W2132246289 @default.
- W3005782880 cites W2136678404 @default.
- W3005782880 cites W2144887013 @default.
- W3005782880 cites W2148690764 @default.
- W3005782880 cites W2171106047 @default.
- W3005782880 cites W2172733717 @default.
- W3005782880 cites W2552908886 @default.
- W3005782880 cites W2586856108 @default.
- W3005782880 cites W2588934593 @default.
- W3005782880 cites W2742060710 @default.
- W3005782880 cites W2743037209 @default.
- W3005782880 cites W2779980451 @default.
- W3005782880 cites W2789239207 @default.
- W3005782880 cites W2888061414 @default.
- W3005782880 cites W2889929594 @default.
- W3005782880 doi "https://doi.org/10.1111/imm.13181" @default.
- W3005782880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7341545" @default.
- W3005782880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32053234" @default.
- W3005782880 hasPublicationYear "2020" @default.
- W3005782880 type Work @default.
- W3005782880 sameAs 3005782880 @default.
- W3005782880 citedByCount "15" @default.
- W3005782880 countsByYear W30057828802020 @default.
- W3005782880 countsByYear W30057828802021 @default.
- W3005782880 countsByYear W30057828802022 @default.
- W3005782880 countsByYear W30057828802023 @default.
- W3005782880 crossrefType "journal-article" @default.
- W3005782880 hasAuthorship W3005782880A5005042323 @default.
- W3005782880 hasAuthorship W3005782880A5010781271 @default.
- W3005782880 hasAuthorship W3005782880A5013881064 @default.
- W3005782880 hasAuthorship W3005782880A5018389673 @default.
- W3005782880 hasAuthorship W3005782880A5024937410 @default.
- W3005782880 hasAuthorship W3005782880A5068383527 @default.
- W3005782880 hasAuthorship W3005782880A5069715775 @default.
- W3005782880 hasBestOaLocation W30057828801 @default.
- W3005782880 hasConcept C136449434 @default.
- W3005782880 hasConcept C159047783 @default.
- W3005782880 hasConcept C171958077 @default.
- W3005782880 hasConcept C203014093 @default.
- W3005782880 hasConcept C2776178377 @default.
- W3005782880 hasConcept C2776709828 @default.
- W3005782880 hasConcept C2776914184 @default.
- W3005782880 hasConcept C2776966659 @default.
- W3005782880 hasConcept C2777003663 @default.
- W3005782880 hasConcept C2778420691 @default.
- W3005782880 hasConcept C2778923194 @default.
- W3005782880 hasConcept C2779341262 @default.