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- W3005850969 abstract "Toxins are usually potent and selective for a given molecular target, and have been frequently used as probes of the structure and function of voltage-gated and ligand-gated ion channels. For these reasons, toxins are of substantial interest, as both pharmacological tools and therapeutic leads. They are, thus, particularly interesting for the pharmaceutical industry. Numerous ion channels constitute important targets for the treatment of neurological or cardiovascular diseases. In addition, the ligand-gated ion channels including nicotinic acetylcholine (nAChR), serotonin type 3 (5-HT3R), γ-aminobutyric acid (GABAAR), and glycine (GlyR) receptors are of great physiological relevance in many neurological disease pathways. In this Special Issue we welcome papers dealing with new toxins and/or new targets from natural sources or from engineering (chemical or recombinant synthesis). Emphasis on toxin-induced biophysical and pharmacological channel modulation, as well as modeling of toxin-target interactions, will be highly appreciated. Additionally, the selection of toxins with well-characterized mode and mechanism of action is relevant, since these toxins may provide scaffolds for drug design studies and will advance our knowledge and understanding of ion channels in common or neglected diseases." @default.
- W3005850969 created "2020-02-24" @default.
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- W3005850969 date "2018-01-01" @default.
- W3005850969 modified "2023-10-03" @default.
- W3005850969 title "Toxins and Ion Channels" @default.
- W3005850969 hasPublicationYear "2018" @default.
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