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- W3005914569 endingPage "103644" @default.
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- W3005914569 abstract "Vitamin D3 (VD3) has been shown to regulate immune function in mammals. 1,25-dihydroxyvitamin (1,25(OH)2D3) is the active form of vitamin D3, which is also known as calcitriol. The current study investigated the immunomodulatory effects of 1,25(OH)2D3 on the innate immune response of yellow catfish (Pelteobagrus fulvidraco) after in vivo and in vitro immune challenge. The in vivo results showed that increasing dietary vitamin D3 decreased mortality, enhanced the immune protective rate, and increased serum lysozyme, catalase and SOD activities in yellow catfish infected with Edwardsiella Ictaluri (p < 0.05). The in vitro results showed that 1,25(OH)2D3 (0, 1, 10, 100, 200 pM) dose-dependently attenuated the rate of apoptosis and production or reactive oxygen species and increased the phagocytic activity of head kidney macrophages stimulated with 10 mg/L lipopolysaccharide (LPS) and 100 mg/L of Poly(I:C) (p < 0.05). Real-time quantitative PCR results showed that increasing dietary vitamin D3 content in vivo and increasing the level of 1,25(OH)2D3 in vitro partially regulated the expression of VD3/VDR-type I interferon axis genes (vdr, irf-3, ifn-a, jak1, stat1, ifi56 and ifp35) after immune challenge. These results indicated that vitamin D3 content helped yellow catfish to resist oxidative stress and inflammation caused by immune challenge, and immunomodulation involved the VD3/VDR-type I interferon action axis." @default.
- W3005914569 created "2020-02-24" @default.
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- W3005914569 date "2020-06-01" @default.
- W3005914569 modified "2023-10-17" @default.
- W3005914569 title "Vitamin D3 modulates yellow catfish (Pelteobagrus fulvidraco) immune function in vivo and in vitro and this involves the vitamin D3/VDR-type I interferon axis" @default.
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- W3005914569 doi "https://doi.org/10.1016/j.dci.2020.103644" @default.
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