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- W3005915420 abstract "This study intends to investigate the mechanisms of ubiqutin-specific protease 22 (USP22)/B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) on the biological phenotypes of glioma stem cells (GSCs) under hypoxia.Western blot, Cell Counting Kit-8, colony formation and flow cytometry assays were preformed to evaluate cells biological behaviors. Luciferase assay was utilized to identify the associations among USP22, HIF-1α and BMI1.Silencing USP22 reduced the stemness and proliferation of GSCs, and increased its apoptosis in response to hypoxia. Whilst, overexpression of BMI1 reversed these phenomena. Whilst, a significant decrease in proliferation and stemness of GSCs caused by HIF-1α exhaustion were inversed by overexpression of USP22 or BMI1.Function of USP22-BMI1 on biological behaviors of GSCs was regulated by HIF-1α in response to hypoxia." @default.
- W3005915420 created "2020-02-24" @default.
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- W3005915420 date "2020-04-01" @default.
- W3005915420 modified "2023-10-01" @default.
- W3005915420 title "Hypoxia-induced USP22-BMI1 axis promotes the stemness and malignancy of glioma stem cells via regulation of HIF-1α" @default.
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- W3005915420 doi "https://doi.org/10.1016/j.lfs.2020.117438" @default.
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