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- W3005981289 abstract "Summary Vertebrates possess paired cranial sensory ganglia derived from two embryonic cell populations, neural crest and placodes. Cranial sensory ganglia arose prior to the divergence of jawed and jawless vertebrates, but the developmental mechanisms that facilitated their evolution are unknown. Using gene expression and cell lineage tracing experiments in embryos of the sea lamprey, Petromyzon marinus , we find that in the cranial ganglia we targeted, development consists of placode‐derived neuron clusters in the core of ganglia, with neural crest cells mostly surrounding these neuronal clusters. To dissect functional roles of neural crest and placode cell associations in these developing cranial ganglia, we used CRISPR/Cas9 gene editing experiments to target genes critical for the development of each population. Genetic ablation of SoxE2 and FoxD ‐ A in neural crest cells resulted in differentiated cranial sensory neurons with abnormal morphologies, whereas deletion of DlxB in cranial placodes resulted in near‐total loss of cranial sensory neurons. Taken together, our cell‐lineage, gene expression, and gene editing results suggest that cranial neural crest cells may not be required for cranial ganglia specification but are essential for shaping the morphology of these sensory structures. We propose that the association of neural crest and placodes in the head of early vertebrates was a key step in the organization of neurons and glia into paired sensory ganglia." @default.
- W3005981289 created "2020-02-24" @default.
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- W3005981289 date "2020-02-12" @default.
- W3005981289 modified "2023-09-30" @default.
- W3005981289 title "Neural crest and placode roles in formation and patterning of cranial sensory ganglia in lamprey" @default.
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- W3005981289 cites W1520125945 @default.
- W3005981289 cites W1563971990 @default.
- W3005981289 cites W1565566882 @default.
- W3005981289 cites W168395010 @default.
- W3005981289 cites W1838681388 @default.
- W3005981289 cites W1894983162 @default.
- W3005981289 cites W1962036314 @default.
- W3005981289 cites W1965343326 @default.
- W3005981289 cites W1967195690 @default.
- W3005981289 cites W1970573822 @default.
- W3005981289 cites W1974276559 @default.
- W3005981289 cites W1976240313 @default.
- W3005981289 cites W1976391205 @default.
- W3005981289 cites W1979538375 @default.
- W3005981289 cites W1979603337 @default.
- W3005981289 cites W1982532675 @default.
- W3005981289 cites W1994125144 @default.
- W3005981289 cites W1995945638 @default.
- W3005981289 cites W1996698511 @default.
- W3005981289 cites W1997035797 @default.
- W3005981289 cites W2001237524 @default.
- W3005981289 cites W2002801240 @default.
- W3005981289 cites W2005302341 @default.
- W3005981289 cites W2015278534 @default.
- W3005981289 cites W2019515947 @default.
- W3005981289 cites W2020448266 @default.
- W3005981289 cites W2020788680 @default.
- W3005981289 cites W2025166290 @default.
- W3005981289 cites W2025700628 @default.
- W3005981289 cites W2029253242 @default.
- W3005981289 cites W2037364812 @default.
- W3005981289 cites W2038434413 @default.
- W3005981289 cites W2044182000 @default.
- W3005981289 cites W2045768277 @default.
- W3005981289 cites W2048010932 @default.
- W3005981289 cites W2048844367 @default.
- W3005981289 cites W2054367286 @default.
- W3005981289 cites W2063894047 @default.
- W3005981289 cites W2064815984 @default.
- W3005981289 cites W2067897880 @default.
- W3005981289 cites W2069789709 @default.
- W3005981289 cites W2075180196 @default.
- W3005981289 cites W2075746875 @default.
- W3005981289 cites W2079800883 @default.
- W3005981289 cites W2080247229 @default.
- W3005981289 cites W2082405869 @default.
- W3005981289 cites W2082619344 @default.
- W3005981289 cites W2083843675 @default.
- W3005981289 cites W2092472216 @default.
- W3005981289 cites W2099326239 @default.
- W3005981289 cites W2100388117 @default.
- W3005981289 cites W2112219106 @default.
- W3005981289 cites W2134374915 @default.
- W3005981289 cites W2144172863 @default.
- W3005981289 cites W2145454156 @default.
- W3005981289 cites W2148146689 @default.
- W3005981289 cites W2152207030 @default.
- W3005981289 cites W2156466651 @default.
- W3005981289 cites W2158572369 @default.
- W3005981289 cites W2160806427 @default.
- W3005981289 cites W2164407811 @default.
- W3005981289 cites W2166884973 @default.
- W3005981289 cites W2168391253 @default.
- W3005981289 cites W2169355027 @default.
- W3005981289 cites W2172213203 @default.
- W3005981289 cites W2183705935 @default.
- W3005981289 cites W2230978262 @default.
- W3005981289 cites W2247844105 @default.
- W3005981289 cites W2294669564 @default.
- W3005981289 cites W2322369524 @default.
- W3005981289 cites W2475548492 @default.
- W3005981289 cites W2479258552 @default.
- W3005981289 cites W2505513234 @default.
- W3005981289 cites W2621591345 @default.
- W3005981289 cites W2625736368 @default.
- W3005981289 cites W2785695887 @default.
- W3005981289 cites W2810713210 @default.
- W3005981289 cites W2887705226 @default.
- W3005981289 cites W2948646155 @default.
- W3005981289 cites W4235074976 @default.
- W3005981289 doi "https://doi.org/10.1002/dvg.23356" @default.
- W3005981289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32049434" @default.
- W3005981289 hasPublicationYear "2020" @default.
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