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- W3005982472 endingPage "107991" @default.
- W3005982472 startingPage "107991" @default.
- W3005982472 abstract "The chronic inability of alcoholics to effectively cope with relapse-inducing stressors has been linked to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and corticotropin-releasing factor (CRF) signaling. However, the cellular mechanisms responsible for this dysregulation are yet to be identified. After exposure of male Sprague Dawley rats to chronic intermittent ethanol (CIE; 5-6 g/kg orally for 35 doses over 50 days) or water, followed by 40-60 days of protracted withdrawal, we investigated CIE effects on glutamatergic synaptic transmission, stress-induced plasticity, CRF- and ethanol-induced NMDAR inhibition using electrophysiological recordings in parvocellular neurosecretory cells (PNCs) of the paraventricular nucleus. We also assessed CIE effects on hypothalamic mRNA expression of CRF-related genes using real-time polymerase chain reaction, and on HPA axis function by measuring stress-induced increases in plasma adrenocorticotropic hormone, corticosterone, and self-grooming. In control rats, ethanol-mediated inhibition of NMDARs was prevented by CRF1 receptor (CRFR1) blockade with antalarmin, while CRF/CRFR1-mediated NMDAR blockade was prevented by intracellularly-applied inhibitor of phosphatases PP1/PP2A, okadaic acid, but not the selective striatal-enriched tyrosine protein phosphatase inhibitor, TC-2153. CIE exposure increased GluN2B subunit-dependent NMDAR function of PNCs. This was associated with the loss of both ethanol- and CRF-mediated NMDAR inhibition, and loss of stress-induced short-term potentiation of glutamatergic synaptic inputs, which could be reversed by intracellular blockade of NMDARs with MK801. CIE exposure also blunted the hormonal and self-grooming behavioral responses to repeated restraint stress. These findings suggest a cellular mechanism whereby chronic alcohol dysregulates the hormonal and behavioral responses to repetitive stressors by increasing NMDAR function and decreasing CRFR1 function." @default.
- W3005982472 created "2020-02-24" @default.
- W3005982472 creator A5007512998 @default.
- W3005982472 creator A5012241599 @default.
- W3005982472 creator A5040499900 @default.
- W3005982472 creator A5049991650 @default.
- W3005982472 date "2020-05-01" @default.
- W3005982472 modified "2023-10-14" @default.
- W3005982472 title "Chronic alcohol disrupts hypothalamic responses to stress by modifying CRF and NMDA receptor function" @default.
- W3005982472 cites W1485094869 @default.
- W3005982472 cites W1488938769 @default.
- W3005982472 cites W1512600172 @default.
- W3005982472 cites W1523733505 @default.
- W3005982472 cites W1529416836 @default.
- W3005982472 cites W1546738173 @default.
- W3005982472 cites W1555529117 @default.
- W3005982472 cites W1608837385 @default.
- W3005982472 cites W1833314573 @default.
- W3005982472 cites W1849093142 @default.
- W3005982472 cites W186829472 @default.
- W3005982472 cites W1902016348 @default.
- W3005982472 cites W1929905538 @default.
- W3005982472 cites W1945497431 @default.
- W3005982472 cites W1961324579 @default.
- W3005982472 cites W1967709356 @default.
- W3005982472 cites W1969697724 @default.
- W3005982472 cites W1971842245 @default.
- W3005982472 cites W1973268693 @default.
- W3005982472 cites W1977587850 @default.
- W3005982472 cites W1977821432 @default.
- W3005982472 cites W1977892054 @default.
- W3005982472 cites W1978249390 @default.
- W3005982472 cites W1979698235 @default.
- W3005982472 cites W1981079130 @default.
- W3005982472 cites W1981518603 @default.
- W3005982472 cites W1981831223 @default.
- W3005982472 cites W1981859408 @default.
- W3005982472 cites W1982435157 @default.
- W3005982472 cites W1982871940 @default.
- W3005982472 cites W1984060648 @default.
- W3005982472 cites W1985744399 @default.
- W3005982472 cites W1986079135 @default.
- W3005982472 cites W1989992663 @default.
- W3005982472 cites W1991882455 @default.
- W3005982472 cites W1993063573 @default.
- W3005982472 cites W1993512624 @default.
- W3005982472 cites W1993645422 @default.
- W3005982472 cites W2000954882 @default.
- W3005982472 cites W2001005368 @default.
- W3005982472 cites W2003436719 @default.
- W3005982472 cites W2003823489 @default.
- W3005982472 cites W2004846311 @default.
- W3005982472 cites W2006684355 @default.
- W3005982472 cites W2007432179 @default.
- W3005982472 cites W2011293417 @default.
- W3005982472 cites W2013144128 @default.
- W3005982472 cites W2015363601 @default.
- W3005982472 cites W2020026669 @default.
- W3005982472 cites W2020841767 @default.
- W3005982472 cites W2021897528 @default.
- W3005982472 cites W2022748226 @default.
- W3005982472 cites W2024036641 @default.
- W3005982472 cites W2025182351 @default.
- W3005982472 cites W2025192622 @default.
- W3005982472 cites W2026849314 @default.
- W3005982472 cites W2027002868 @default.
- W3005982472 cites W2028101732 @default.
- W3005982472 cites W2028862108 @default.
- W3005982472 cites W2029332045 @default.
- W3005982472 cites W2029677928 @default.
- W3005982472 cites W2031067320 @default.
- W3005982472 cites W2033312407 @default.
- W3005982472 cites W2036994812 @default.
- W3005982472 cites W2037249096 @default.
- W3005982472 cites W2043524974 @default.
- W3005982472 cites W2045165595 @default.
- W3005982472 cites W2045358091 @default.
- W3005982472 cites W2047517404 @default.
- W3005982472 cites W2047522679 @default.
- W3005982472 cites W2049614210 @default.
- W3005982472 cites W2050487909 @default.
- W3005982472 cites W2050750919 @default.
- W3005982472 cites W2052104518 @default.
- W3005982472 cites W2055758379 @default.
- W3005982472 cites W2061888516 @default.
- W3005982472 cites W2064055939 @default.
- W3005982472 cites W2064794291 @default.
- W3005982472 cites W2065577847 @default.
- W3005982472 cites W2066183427 @default.
- W3005982472 cites W2067707492 @default.
- W3005982472 cites W2068015354 @default.
- W3005982472 cites W2068121981 @default.
- W3005982472 cites W2070065061 @default.
- W3005982472 cites W2072212361 @default.
- W3005982472 cites W2072454094 @default.
- W3005982472 cites W2073537077 @default.
- W3005982472 cites W2074244295 @default.
- W3005982472 cites W2074676469 @default.