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- W3005983687 abstract "Abstract Background The Food Quality Protection Act of 1996, or FQPA, required the Environmental Protection Agency to set allowable levels for pesticides in a way that would “ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue.” The act stipulated that an additional tenfold margin of safety for pesticide risk assessments shall be applied to account for pre- and postnatal toxicity and for any data gaps regarding pesticide exposure and toxicity, unless there are reliable data to demonstrate that a different margin would be safe for infants and children. Discussion To examine the implementation of the FQPA-mandated additional margin of safety, this analysis reviews 59 pesticide risk assessments published by the EPA between 2011 and 2019. The list includes 12 pesticides used in the largest amount in the U.S.; a group of 35 pesticides detected on fruits and vegetables; and 12 organophosphate pesticides. For the non-organophosphate pesticides reviewed here, the EPA applied an additional children’s health safety factor in 13% of acute dietary exposure scenarios and 12% of chronic dietary exposure scenarios. For incidental oral, dermal and inhalation exposures, additional FQPA factors were applied for 15, 31, and 41%, respectively, of the non-organophosphate pesticides, primarily due to data uncertainties. For the organophosphate pesticides as a group, a tenfold children’s health safety factor was proposed in 2015. Notably, in 2017 that decision was reversed for chlorpyrifos. Conclusions For the majority of pesticides reviewed in this study, the EPA did not apply an additional FQPA safety factor, missing an opportunity to fully use the FQPA authority for protecting children’s health." @default.
- W3005983687 created "2020-02-24" @default.
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- W3005983687 date "2020-02-10" @default.
- W3005983687 modified "2023-10-14" @default.
- W3005983687 title "Application of the Food Quality Protection Act children’s health safety factor in the U.S. EPA pesticide risk assessments" @default.
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- W3005983687 doi "https://doi.org/10.1186/s12940-020-0571-6" @default.
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