Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005984622> ?p ?o ?g. }
- W3005984622 endingPage "102334" @default.
- W3005984622 startingPage "102334" @default.
- W3005984622 abstract "Pain and vaso-occlusive crises (VOC) are hallmark complications of sickle cell disease (SCD) and result in significant physical and psychosocial impairment. The variability in SCD pain frequency and triggers for the transition from steady state to VOC are not well understood. This paper summarizes the harmful physiological effects of pain and emotional stressors on autonomically-mediated vascular function in individuals with SCD and the effects of a cognitive, neuromodulatory intervention (i.e. hypnosis) on microvascular blood flow. We reviewed recent studies from the authors' vascular physiology laboratory that assessed microvascular responses to laboratory stressors in individuals with SCD. Results indicate that participants with SCD exhibit marked neurally mediated vascular reactivity in response to pain, pain-related fear, and mental stress. Further, pilot study results show that engagement in hypnosis may attenuate harmful microvascular responses to pain. The collective results demonstrate that autonomically-mediated vascular responses to pain and mental stress represent an important SCD intervention target. This ongoing work provides physiological justification for the inclusion of cognitive, neuromodulatory and complementary treatments in SCD disease management and may inform the development of targeted, integrative interventions that prevent the enhancement of autonomic vascular dysfunction in SCD." @default.
- W3005984622 created "2020-02-24" @default.
- W3005984622 creator A5003711107 @default.
- W3005984622 creator A5013496531 @default.
- W3005984622 creator A5014467386 @default.
- W3005984622 creator A5022516191 @default.
- W3005984622 creator A5023745730 @default.
- W3005984622 creator A5035086825 @default.
- W3005984622 creator A5077729374 @default.
- W3005984622 date "2020-03-01" @default.
- W3005984622 modified "2023-09-24" @default.
- W3005984622 title "Autonomically-mediated decrease in microvascular blood flow due to mental stress and pain in sickle cell disease: A target for neuromodulatory interventions" @default.
- W3005984622 cites W1489692832 @default.
- W3005984622 cites W1963574634 @default.
- W3005984622 cites W1964235253 @default.
- W3005984622 cites W1975953969 @default.
- W3005984622 cites W1978839569 @default.
- W3005984622 cites W1979657039 @default.
- W3005984622 cites W1985623917 @default.
- W3005984622 cites W1986400563 @default.
- W3005984622 cites W1995423921 @default.
- W3005984622 cites W2009428902 @default.
- W3005984622 cites W2023039510 @default.
- W3005984622 cites W2029274378 @default.
- W3005984622 cites W2031151413 @default.
- W3005984622 cites W2035356574 @default.
- W3005984622 cites W2039525655 @default.
- W3005984622 cites W2057320092 @default.
- W3005984622 cites W2060003600 @default.
- W3005984622 cites W2065687898 @default.
- W3005984622 cites W2067442764 @default.
- W3005984622 cites W2073126972 @default.
- W3005984622 cites W2076878248 @default.
- W3005984622 cites W2080996329 @default.
- W3005984622 cites W2087025337 @default.
- W3005984622 cites W2095583963 @default.
- W3005984622 cites W2099306784 @default.
- W3005984622 cites W2103531213 @default.
- W3005984622 cites W2130612005 @default.
- W3005984622 cites W2135233078 @default.
- W3005984622 cites W2149395830 @default.
- W3005984622 cites W2150704745 @default.
- W3005984622 cites W2152817096 @default.
- W3005984622 cites W2164675587 @default.
- W3005984622 cites W2164740960 @default.
- W3005984622 cites W2268983801 @default.
- W3005984622 cites W2322074970 @default.
- W3005984622 cites W2324965719 @default.
- W3005984622 cites W2516840298 @default.
- W3005984622 cites W2522696021 @default.
- W3005984622 cites W2605965249 @default.
- W3005984622 cites W2617345575 @default.
- W3005984622 cites W2735099997 @default.
- W3005984622 cites W2735562956 @default.
- W3005984622 cites W2756434035 @default.
- W3005984622 cites W2795199665 @default.
- W3005984622 cites W2895377273 @default.
- W3005984622 cites W2915025664 @default.
- W3005984622 cites W2922853059 @default.
- W3005984622 cites W4248205301 @default.
- W3005984622 doi "https://doi.org/10.1016/j.ctim.2020.102334" @default.
- W3005984622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7640987" @default.
- W3005984622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32147052" @default.
- W3005984622 hasPublicationYear "2020" @default.
- W3005984622 type Work @default.
- W3005984622 sameAs 3005984622 @default.
- W3005984622 citedByCount "3" @default.
- W3005984622 countsByYear W30059846222022 @default.
- W3005984622 countsByYear W30059846222023 @default.
- W3005984622 crossrefType "journal-article" @default.
- W3005984622 hasAuthorship W3005984622A5003711107 @default.
- W3005984622 hasAuthorship W3005984622A5013496531 @default.
- W3005984622 hasAuthorship W3005984622A5014467386 @default.
- W3005984622 hasAuthorship W3005984622A5022516191 @default.
- W3005984622 hasAuthorship W3005984622A5023745730 @default.
- W3005984622 hasAuthorship W3005984622A5035086825 @default.
- W3005984622 hasAuthorship W3005984622A5077729374 @default.
- W3005984622 hasBestOaLocation W30059846222 @default.
- W3005984622 hasConcept C118552586 @default.
- W3005984622 hasConcept C126322002 @default.
- W3005984622 hasConcept C158846371 @default.
- W3005984622 hasConcept C1862650 @default.
- W3005984622 hasConcept C27415008 @default.
- W3005984622 hasConcept C2779134260 @default.
- W3005984622 hasConcept C2984493583 @default.
- W3005984622 hasConcept C71924100 @default.
- W3005984622 hasConcept C99508421 @default.
- W3005984622 hasConceptScore W3005984622C118552586 @default.
- W3005984622 hasConceptScore W3005984622C126322002 @default.
- W3005984622 hasConceptScore W3005984622C158846371 @default.
- W3005984622 hasConceptScore W3005984622C1862650 @default.
- W3005984622 hasConceptScore W3005984622C27415008 @default.
- W3005984622 hasConceptScore W3005984622C2779134260 @default.
- W3005984622 hasConceptScore W3005984622C2984493583 @default.
- W3005984622 hasConceptScore W3005984622C71924100 @default.
- W3005984622 hasConceptScore W3005984622C99508421 @default.
- W3005984622 hasFunder F4320320334 @default.
- W3005984622 hasLocation W30059846221 @default.