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- W3005984791 abstract "Abstract Apart from some model organisms, the interactome of most organisms is largely unidentified. High-throughput experimental techniques to determine protein-protein interactions (PPIs) are resource intensive and highly susceptible to noise. Computational methods of PPI determination can accelerate biological discovery by identifying the most promising interacting pairs of proteins and by assessing the reliability of identified PPIs. Here we present a first in-depth study describing a global view of the ant Camponotus floridanus interactome. Although several ant genomes have been sequenced in the last eight years, studies exploring and investigating PPIs in ants are lacking. Our study attempts to fill this gap and the presented interactome will also serve as a template for determining PPIs in other ants in future. Our C. floridanus interactome covers 51,866 non-redundant PPIs among 6,274 proteins, including 20,544 interactions supported by domain-domain interactions (DDIs), 13,640 interactions supported by DDIs and subcellular localization, and 10,834 high confidence interactions mediated by 3,289 proteins. These interactions involve and cover 30.6% of the entire C. floridanus proteome." @default.
- W3005984791 created "2020-02-24" @default.
- W3005984791 creator A5025345707 @default.
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- W3005984791 creator A5074491779 @default.
- W3005984791 creator A5086202312 @default.
- W3005984791 date "2020-02-11" @default.
- W3005984791 modified "2023-10-14" @default.
- W3005984791 title "Genome-wide inference of the Camponotus floridanus protein-protein interaction network using homologous mapping and interacting domain profile pairs" @default.
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- W3005984791 doi "https://doi.org/10.1038/s41598-020-59344-1" @default.
- W3005984791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7012867" @default.
- W3005984791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32047225" @default.
- W3005984791 hasPublicationYear "2020" @default.
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