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- W3006009743 abstract "Graphene-based biosensors can be produced in a scalable manner at reasonable cost, and they show significant promise for sensitive detection of small molecules and biomarkers such as proteins, single strand nucleic acids, and drug targets. Here, we describe an approach that enables a limit of detection of ~1 aM for a ssDNA target without amplification. We also show that a sensor based on a short (20mer) probe complementary to a portion of a longer (100mer) target provides enhanced sensitivity and saturation signal level. Finally, we show that graphene-based DNA biosensors can be repeatedly recycled with consistent sensor responses by melting off bound target strands. These results show the potential utility of this technology in nucleic acid detection for disease diagnostics." @default.
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- W3006009743 date "2020-06-01" @default.
- W3006009743 modified "2023-10-18" @default.
- W3006009743 title "Attomolar Detection of ssDNA Without Amplification and Capture of Long Target Sequences With Graphene Biosensors" @default.
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- W3006009743 doi "https://doi.org/10.1109/jsen.2020.2973949" @default.
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