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• W3006023246 abstract "Laboratory automation strategies have vast potential for accelerating discovery processes. They enable higher efficiency and throughput for time-consuming screening procedures and reduce error-prone manual steps. Automating repetitive procedures can for instance support chemists in optimizing chemical reactions. Particularly, the technology of DNA-encoded libraries (DELs) may benefit from automation techniques, since translation of chemical reactions to DNA-tagged reactants often requires screening of multiple reaction parameters and evaluation of large numbers of reactants. Here, we describe a portable, automated system for reagent dispensing that was designed from open source materials. The system was validated by performing amide coupling of carboxylic acids to DNA-linked amine and a micelle-mediated Povarov reaction to DNA-tagged hexahydropyrroloquinolines. The latter reaction required accurate pipetting of multiple components including different solvents and a surface-active reagent. Analysis of reactions demonstrated that the robotic system achieved high accuracy comparable to experimentation by an experienced chemist with the potential of higher throughput." @default.
• W3006023246 created "2020-02-24" @default.
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• W3006023246 date "2020-02-13" @default.
• W3006023246 modified "2023-10-02" @default.
• W3006023246 title "Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-Tagged Substrates" @default.
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• W3006023246 doi "https://doi.org/10.1021/acscombsci.9b00207" @default.
• W3006023246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32053337" @default.
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