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- W3006107084 endingPage "152" @default.
- W3006107084 startingPage "152" @default.
- W3006107084 abstract ": The transdermal route of drugs has received increased attention in recent years due to numerous advantages over the oral and injectable routes, such as avoidance of the hepatic metabolism, protection of drugs from the gastrointestinal tract, sustained drug delivery, and good patient compliance. The assessment of ex vivo permeation during the pharmaceutical development process helps in understanding the product quality and performance of a transdermal delivery system. Generally, excised human skin relevant to the application site or animal skin is recommended for ex vivo permeation studies. However, the limited availability of the human skin and ethical issues surrounding the use of animal skin rendered these models less attractive in the permeation study. In the last three decades, enormous efforts have been put into developing artificial membranes and 3D cultured human skin models as surrogates to the human skin. This manuscript provides an insight on the European Medicines Agency (EMA) guidelines for permeation studies and the parameters affected when using Franz diffusion cells in the permeation study. The need and possibilities for skin alternatives, such as artificially cultured human skin models, parallel artificial membrane permeability assays (PAMPA), and artificial membranes for penetration and permeation studies, are comprehensively discussed." @default.
- W3006107084 created "2020-02-24" @default.
- W3006107084 creator A5004261103 @default.
- W3006107084 creator A5022422688 @default.
- W3006107084 creator A5048176348 @default.
- W3006107084 creator A5071215928 @default.
- W3006107084 creator A5080251199 @default.
- W3006107084 date "2020-02-13" @default.
- W3006107084 modified "2023-10-14" @default.
- W3006107084 title "Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities" @default.
- W3006107084 cites W1210654754 @default.
- W3006107084 cites W1561210178 @default.
- W3006107084 cites W1862421161 @default.
- W3006107084 cites W1896845449 @default.
- W3006107084 cites W1976555397 @default.
- W3006107084 cites W1978283154 @default.
- W3006107084 cites W1984014633 @default.
- W3006107084 cites W1991966167 @default.
- W3006107084 cites W1995416495 @default.
- W3006107084 cites W1999313103 @default.
- W3006107084 cites W2000574141 @default.
- W3006107084 cites W2003157125 @default.
- W3006107084 cites W2004926660 @default.
- W3006107084 cites W2005158694 @default.
- W3006107084 cites W2008283751 @default.
- W3006107084 cites W2008643614 @default.
- W3006107084 cites W2017213361 @default.
- W3006107084 cites W2017576139 @default.
- W3006107084 cites W2019840972 @default.
- W3006107084 cites W2021430749 @default.
- W3006107084 cites W2021820072 @default.
- W3006107084 cites W2024858427 @default.
- W3006107084 cites W2024928651 @default.
- W3006107084 cites W2027462520 @default.
- W3006107084 cites W2027574764 @default.
- W3006107084 cites W2030725256 @default.
- W3006107084 cites W2031057832 @default.
- W3006107084 cites W2033183247 @default.
- W3006107084 cites W2035243146 @default.
- W3006107084 cites W2037005592 @default.
- W3006107084 cites W2041192818 @default.
- W3006107084 cites W2046393507 @default.
- W3006107084 cites W2050890076 @default.
- W3006107084 cites W2054271813 @default.
- W3006107084 cites W2054557776 @default.
- W3006107084 cites W2056278520 @default.
- W3006107084 cites W2060273005 @default.
- W3006107084 cites W2063567276 @default.
- W3006107084 cites W2064167266 @default.
- W3006107084 cites W2069185355 @default.
- W3006107084 cites W2080430067 @default.
- W3006107084 cites W2080882412 @default.
- W3006107084 cites W2088777882 @default.
- W3006107084 cites W2092979692 @default.
- W3006107084 cites W2093329706 @default.
- W3006107084 cites W2093351570 @default.
- W3006107084 cites W2093405013 @default.
- W3006107084 cites W2093873280 @default.
- W3006107084 cites W2095067107 @default.
- W3006107084 cites W2096843498 @default.
- W3006107084 cites W2097695518 @default.
- W3006107084 cites W2108016556 @default.
- W3006107084 cites W2121605320 @default.
- W3006107084 cites W2130339953 @default.
- W3006107084 cites W2138749064 @default.
- W3006107084 cites W2142528678 @default.
- W3006107084 cites W2156407047 @default.
- W3006107084 cites W2163624874 @default.
- W3006107084 cites W2164632606 @default.
- W3006107084 cites W2165105357 @default.
- W3006107084 cites W2168292600 @default.
- W3006107084 cites W2172187417 @default.
- W3006107084 cites W2174770193 @default.
- W3006107084 cites W2229475392 @default.
- W3006107084 cites W2250289161 @default.
- W3006107084 cites W2257277670 @default.
- W3006107084 cites W2286538952 @default.
- W3006107084 cites W2308711581 @default.
- W3006107084 cites W2310216621 @default.
- W3006107084 cites W2319951151 @default.
- W3006107084 cites W2332139540 @default.
- W3006107084 cites W2413670321 @default.
- W3006107084 cites W2461979478 @default.
- W3006107084 cites W246233814 @default.
- W3006107084 cites W2498567072 @default.
- W3006107084 cites W2505735841 @default.
- W3006107084 cites W2508103705 @default.
- W3006107084 cites W2516805626 @default.
- W3006107084 cites W2517606523 @default.
- W3006107084 cites W2532874665 @default.
- W3006107084 cites W2544262128 @default.
- W3006107084 cites W2548761413 @default.
- W3006107084 cites W2558981100 @default.
- W3006107084 cites W2572592638 @default.
- W3006107084 cites W2592987913 @default.
- W3006107084 cites W2595869030 @default.
- W3006107084 cites W2752790083 @default.
- W3006107084 cites W2766624429 @default.