Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006170349> ?p ?o ?g. }
- W3006170349 endingPage "492" @default.
- W3006170349 startingPage "492" @default.
- W3006170349 abstract "To characterise the dynamic of events during the early phases of fracture repair in humans, we investigated molecular events using gene expression profiling of bone fragments from the fracture site at different time points after trauma and immune/stromal cells recruitment at the fracture site using flow cytometry. Bone and inflammatory markers were expressed at low levels at homeostasis, while transcripts for bone constituent proteins were consistently detected at higher levels. Early after fracture (range 2–4 days), increased expression of CXCL12, suggested recruitment of immune cells associated with a change in the balance of degradation enzymes and their inhibitors. At intermediate time after fracture (4–8 days), we observed high expression of inflammatory cytokines (IL1-beta, IL6), CCL2, the T-cell activation marker CD69. Late after fracture (8–14 days), high expression of factors co-operating towards the regulation of bone turnover was detected. We identified potential soluble factors and explored circulating levels in patients for whom a union/non-union (U/NU) outcome was known. This showed a clear difference for PlGF (p = 0.003) at day 1. These findings can inform future studies further investigating the cascade of molecular events following fractures and for the prediction of fracture non-union." @default.
- W3006170349 created "2020-02-24" @default.
- W3006170349 creator A5010798251 @default.
- W3006170349 creator A5012043848 @default.
- W3006170349 creator A5033400134 @default.
- W3006170349 creator A5051963524 @default.
- W3006170349 creator A5085000703 @default.
- W3006170349 creator A5089355140 @default.
- W3006170349 date "2020-02-11" @default.
- W3006170349 modified "2023-10-02" @default.
- W3006170349 title "Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans" @default.
- W3006170349 cites W1554718189 @default.
- W3006170349 cites W1968720475 @default.
- W3006170349 cites W1980593913 @default.
- W3006170349 cites W1985104169 @default.
- W3006170349 cites W1989933525 @default.
- W3006170349 cites W1997697459 @default.
- W3006170349 cites W2014353292 @default.
- W3006170349 cites W2016704225 @default.
- W3006170349 cites W2023225986 @default.
- W3006170349 cites W2024133931 @default.
- W3006170349 cites W2036557984 @default.
- W3006170349 cites W2045564964 @default.
- W3006170349 cites W2050754818 @default.
- W3006170349 cites W2060038073 @default.
- W3006170349 cites W2063275094 @default.
- W3006170349 cites W2063549145 @default.
- W3006170349 cites W2074226229 @default.
- W3006170349 cites W2083255104 @default.
- W3006170349 cites W2086421586 @default.
- W3006170349 cites W2087972194 @default.
- W3006170349 cites W2097492875 @default.
- W3006170349 cites W2097881605 @default.
- W3006170349 cites W2109293470 @default.
- W3006170349 cites W2114604396 @default.
- W3006170349 cites W2123077948 @default.
- W3006170349 cites W2124273389 @default.
- W3006170349 cites W2147896327 @default.
- W3006170349 cites W2149271086 @default.
- W3006170349 cites W2163768016 @default.
- W3006170349 cites W2171768590 @default.
- W3006170349 cites W2200635643 @default.
- W3006170349 cites W2320736181 @default.
- W3006170349 cites W2332018470 @default.
- W3006170349 cites W2519052568 @default.
- W3006170349 cites W2593443421 @default.
- W3006170349 cites W2603901680 @default.
- W3006170349 cites W2783694426 @default.
- W3006170349 cites W2793888838 @default.
- W3006170349 cites W2803017273 @default.
- W3006170349 cites W2808782307 @default.
- W3006170349 cites W2885280408 @default.
- W3006170349 cites W2904072138 @default.
- W3006170349 cites W94996060 @default.
- W3006170349 doi "https://doi.org/10.3390/jcm9020492" @default.
- W3006170349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7073571" @default.
- W3006170349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32054088" @default.
- W3006170349 hasPublicationYear "2020" @default.
- W3006170349 type Work @default.
- W3006170349 sameAs 3006170349 @default.
- W3006170349 citedByCount "16" @default.
- W3006170349 countsByYear W30061703492020 @default.
- W3006170349 countsByYear W30061703492021 @default.
- W3006170349 countsByYear W30061703492022 @default.
- W3006170349 countsByYear W30061703492023 @default.
- W3006170349 crossrefType "journal-article" @default.
- W3006170349 hasAuthorship W3006170349A5010798251 @default.
- W3006170349 hasAuthorship W3006170349A5012043848 @default.
- W3006170349 hasAuthorship W3006170349A5033400134 @default.
- W3006170349 hasAuthorship W3006170349A5051963524 @default.
- W3006170349 hasAuthorship W3006170349A5085000703 @default.
- W3006170349 hasAuthorship W3006170349A5089355140 @default.
- W3006170349 hasBestOaLocation W30061703491 @default.
- W3006170349 hasConcept C126322002 @default.
- W3006170349 hasConcept C126838900 @default.
- W3006170349 hasConcept C134018914 @default.
- W3006170349 hasConcept C141071460 @default.
- W3006170349 hasConcept C164027704 @default.
- W3006170349 hasConcept C170033053 @default.
- W3006170349 hasConcept C203014093 @default.
- W3006170349 hasConcept C2776441800 @default.
- W3006170349 hasConcept C2776914184 @default.
- W3006170349 hasConcept C553184892 @default.
- W3006170349 hasConcept C63645605 @default.
- W3006170349 hasConcept C71924100 @default.
- W3006170349 hasConcept C8337478 @default.
- W3006170349 hasConcept C8891405 @default.
- W3006170349 hasConceptScore W3006170349C126322002 @default.
- W3006170349 hasConceptScore W3006170349C126838900 @default.
- W3006170349 hasConceptScore W3006170349C134018914 @default.
- W3006170349 hasConceptScore W3006170349C141071460 @default.
- W3006170349 hasConceptScore W3006170349C164027704 @default.
- W3006170349 hasConceptScore W3006170349C170033053 @default.
- W3006170349 hasConceptScore W3006170349C203014093 @default.
- W3006170349 hasConceptScore W3006170349C2776441800 @default.
- W3006170349 hasConceptScore W3006170349C2776914184 @default.
- W3006170349 hasConceptScore W3006170349C553184892 @default.
- W3006170349 hasConceptScore W3006170349C63645605 @default.