FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006242222> ?p ?o ?g. }

• W3006242222 endingPage "2554" @default.
• W3006242222 startingPage "2546" @default.
• W3006242222 abstract "A key aim of post-genomic biomedical research is to systematically understand molecules and their interactions in human cells. Multiple biomolecules coordinate to sustain life activities, and interactions between various biomolecules are interconnected. However, existing studies usually only focusing on associations between two or very limited types of molecules. In this study, we propose a network representation learning based computational framework MAN-SDNE to predict any intermolecular associations. More specifically, we constructed a large-scale molecular association network of multiple biomolecules in human by integrating associations among long non-coding RNA, microRNA, protein, drug, and disease, containing 6,528 molecular nodes, 9 kind of,105,546 associations. And then, the feature of each node is represented by its network proximity and attribute features. Furthermore, these features are used to train Random Forest classifier to predict intermolecular associations. MAN-SDNE achieves a remarkable performance with an AUC of 0.9552 and an AUPR of 0.9338 under five-fold cross-validation. To indicate the ability to predict specific types of interactions, a case study for predicting lncRNA-protein interactions using MAN-SDNE is also executed. Experimental results demonstrate this work offers a systematic insight for understanding the synergistic associations between molecules and complex diseases and provides a network-based computational tool to systematically explore intermolecular interactions." @default.
• W3006242222 created "2020-02-24" @default.
• W3006242222 creator A5014121271 @default.
• W3006242222 creator A5019054788 @default.
• W3006242222 creator A5060381913 @default.
• W3006242222 creator A5082017081 @default.
• W3006242222 creator A5091608695 @default.
• W3006242222 date "2021-11-01" @default.
• W3006242222 modified "2023-10-11" @default.
• W3006242222 title "Learning Representation of Molecules in Association Network for Predicting Intermolecular Associations" @default.
• W3006242222 cites W1158178075 @default.
• W3006242222 cites W1193984273 @default.
• W3006242222 cites W1975147762 @default.
• W3006242222 cites W1982267716 @default.
• W3006242222 cites W2003494331 @default.
• W3006242222 cites W2039244683 @default.
• W3006242222 cites W2053186076 @default.
• W3006242222 cites W2090891622 @default.
• W3006242222 cites W2103368657 @default.
• W3006242222 cites W2128983843 @default.
• W3006242222 cites W2136640051 @default.
• W3006242222 cites W2137734450 @default.
• W3006242222 cites W2155004936 @default.
• W3006242222 cites W2171466942 @default.
• W3006242222 cites W2313125707 @default.
• W3006242222 cites W2315196278 @default.
• W3006242222 cites W2322763599 @default.
• W3006242222 cites W2393319904 @default.
• W3006242222 cites W2537623931 @default.
• W3006242222 cites W2537679995 @default.
• W3006242222 cites W2590019597 @default.
• W3006242222 cites W2601934706 @default.
• W3006242222 cites W2607802139 @default.
• W3006242222 cites W2748551035 @default.
• W3006242222 cites W2753550436 @default.
• W3006242222 cites W2766950760 @default.
• W3006242222 cites W2767061187 @default.
• W3006242222 cites W2767546566 @default.
• W3006242222 cites W2767891136 @default.
• W3006242222 cites W2782735072 @default.
• W3006242222 cites W2786247882 @default.
• W3006242222 cites W2793344725 @default.
• W3006242222 cites W2800766678 @default.
• W3006242222 cites W2805643613 @default.
• W3006242222 cites W2807587597 @default.
• W3006242222 cites W2809867059 @default.
• W3006242222 cites W2895615116 @default.
• W3006242222 cites W2896725104 @default.
• W3006242222 cites W2897252949 @default.
• W3006242222 cites W2899288360 @default.
• W3006242222 cites W2903096015 @default.
• W3006242222 cites W2903959374 @default.
• W3006242222 cites W2916047525 @default.
• W3006242222 cites W2922930052 @default.
• W3006242222 cites W2923922207 @default.
• W3006242222 cites W3104097132 @default.
• W3006242222 cites W3105705953 @default.
• W3006242222 cites W4246271082 @default.
• W3006242222 cites W4291474301 @default.
• W3006242222 doi "https://doi.org/10.1109/tcbb.2020.2973091" @default.
• W3006242222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32070992" @default.
• W3006242222 hasPublicationYear "2021" @default.
• W3006242222 type Work @default.
• W3006242222 sameAs 3006242222 @default.
• W3006242222 citedByCount "17" @default.
• W3006242222 countsByYear W30062422222020 @default.
• W3006242222 countsByYear W30062422222021 @default.
• W3006242222 countsByYear W30062422222022 @default.
• W3006242222 countsByYear W30062422222023 @default.
• W3006242222 crossrefType "journal-article" @default.
• W3006242222 hasAuthorship W3006242222A5014121271 @default.
• W3006242222 hasAuthorship W3006242222A5019054788 @default.
• W3006242222 hasAuthorship W3006242222A5060381913 @default.
• W3006242222 hasAuthorship W3006242222A5082017081 @default.
• W3006242222 hasAuthorship W3006242222A5091608695 @default.
• W3006242222 hasConcept C119857082 @default.
• W3006242222 hasConcept C142853389 @default.
• W3006242222 hasConcept C154945302 @default.
• W3006242222 hasConcept C15744967 @default.
• W3006242222 hasConcept C166950319 @default.
• W3006242222 hasConcept C171250308 @default.
• W3006242222 hasConcept C17744445 @default.
• W3006242222 hasConcept C178790620 @default.
• W3006242222 hasConcept C185592680 @default.
• W3006242222 hasConcept C192562407 @default.
• W3006242222 hasConcept C199539241 @default.
• W3006242222 hasConcept C2776359362 @default.
• W3006242222 hasConcept C28225019 @default.
• W3006242222 hasConcept C32909587 @default.
• W3006242222 hasConcept C41008148 @default.
• W3006242222 hasConcept C49853544 @default.
• W3006242222 hasConcept C542102704 @default.
• W3006242222 hasConcept C70721500 @default.
• W3006242222 hasConcept C86803240 @default.
• W3006242222 hasConcept C94625758 @default.
• W3006242222 hasConceptScore W3006242222C119857082 @default.
• W3006242222 hasConceptScore W3006242222C142853389 @default.
• W3006242222 hasConceptScore W3006242222C154945302 @default.

• next