Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006242327> ?p ?o ?g. }
- W3006242327 endingPage "638" @default.
- W3006242327 startingPage "627" @default.
- W3006242327 abstract "We aimed to evaluate the therapeutic effects of exosomes, which were collected from human neuroepithelial stem cells (HNESCs) treated by miR-29b mimics, on the treatment of spinal cord injury (SCI). Computational analysis, real-time PCR, Western blot analysis and TUNEL assay, a BBB score system, the Nissl staining and IHC assay were conducted to explore the molecular signalling pathway underlying the function of exosomes in SCI. Exosomes isolated from cells treated with HNESC exhibited the strongest inhibitory effect on cell apoptosis while exhibiting the highest level of miR-29b expression and the lowest levels of PTEN and caspase-3 expression. Moreover, PTEN and caspase-3 were identified as the direct target genes of miR-29b. The exosomes isolated from the groups of HNESC and HNESC + miR-29b mimics exhibited in vivo therapeutic effects by restoring the BBB score and apoptosis index of post-SCI neuron cells to those of normal neuron cells, with the exosomes collected from the group of HNESC + miR-29b mimics showing the strongest effect. We suggested that the exosomes derived from the group of HNESC + miR-29b mimics exerted therapeutic effects on SCI by down-regulating the expression of PTEN/caspase-3 and subsequently suppressing the apoptosis of neuron cells." @default.
- W3006242327 created "2020-02-24" @default.
- W3006242327 creator A5005658067 @default.
- W3006242327 creator A5014027426 @default.
- W3006242327 creator A5020487588 @default.
- W3006242327 creator A5025389738 @default.
- W3006242327 creator A5055327423 @default.
- W3006242327 creator A5068568550 @default.
- W3006242327 creator A5077539959 @default.
- W3006242327 date "2020-01-01" @default.
- W3006242327 modified "2023-10-02" @default.
- W3006242327 title "RETRACTED ARTICLE: Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury" @default.
- W3006242327 cites W1524589668 @default.
- W3006242327 cites W1566509581 @default.
- W3006242327 cites W1845459216 @default.
- W3006242327 cites W1963528166 @default.
- W3006242327 cites W1965306643 @default.
- W3006242327 cites W1966806455 @default.
- W3006242327 cites W1974432822 @default.
- W3006242327 cites W1979961040 @default.
- W3006242327 cites W1986630370 @default.
- W3006242327 cites W1986819225 @default.
- W3006242327 cites W2002995168 @default.
- W3006242327 cites W2006011498 @default.
- W3006242327 cites W2016094394 @default.
- W3006242327 cites W2016565452 @default.
- W3006242327 cites W2026246891 @default.
- W3006242327 cites W2031861741 @default.
- W3006242327 cites W2035086650 @default.
- W3006242327 cites W2040923206 @default.
- W3006242327 cites W2051094421 @default.
- W3006242327 cites W2055313665 @default.
- W3006242327 cites W2067013656 @default.
- W3006242327 cites W2067751798 @default.
- W3006242327 cites W2068427129 @default.
- W3006242327 cites W2075514051 @default.
- W3006242327 cites W2076731990 @default.
- W3006242327 cites W2077047479 @default.
- W3006242327 cites W2093684206 @default.
- W3006242327 cites W2099356747 @default.
- W3006242327 cites W2100932663 @default.
- W3006242327 cites W2113561239 @default.
- W3006242327 cites W2122159093 @default.
- W3006242327 cites W2123166021 @default.
- W3006242327 cites W2130731229 @default.
- W3006242327 cites W2139791626 @default.
- W3006242327 cites W2141310245 @default.
- W3006242327 cites W2158048826 @default.
- W3006242327 cites W2159801541 @default.
- W3006242327 cites W2163643958 @default.
- W3006242327 cites W2240063722 @default.
- W3006242327 cites W2329818534 @default.
- W3006242327 cites W2407890550 @default.
- W3006242327 cites W2888312828 @default.
- W3006242327 cites W2889559822 @default.
- W3006242327 cites W2894856913 @default.
- W3006242327 cites W2898164189 @default.
- W3006242327 cites W2906134240 @default.
- W3006242327 cites W2910366576 @default.
- W3006242327 cites W4294309388 @default.
- W3006242327 doi "https://doi.org/10.1080/21691401.2020.1725031" @default.
- W3006242327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32054316" @default.
- W3006242327 hasPublicationYear "2020" @default.
- W3006242327 type Work @default.
- W3006242327 sameAs 3006242327 @default.
- W3006242327 citedByCount "13" @default.
- W3006242327 countsByYear W30062423272021 @default.
- W3006242327 countsByYear W30062423272022 @default.
- W3006242327 countsByYear W30062423272023 @default.
- W3006242327 crossrefType "journal-article" @default.
- W3006242327 hasAuthorship W3006242327A5005658067 @default.
- W3006242327 hasAuthorship W3006242327A5014027426 @default.
- W3006242327 hasAuthorship W3006242327A5020487588 @default.
- W3006242327 hasAuthorship W3006242327A5025389738 @default.
- W3006242327 hasAuthorship W3006242327A5055327423 @default.
- W3006242327 hasAuthorship W3006242327A5068568550 @default.
- W3006242327 hasAuthorship W3006242327A5077539959 @default.
- W3006242327 hasBestOaLocation W30062423271 @default.
- W3006242327 hasConcept C104317684 @default.
- W3006242327 hasConcept C145059251 @default.
- W3006242327 hasConcept C169760540 @default.
- W3006242327 hasConcept C190283241 @default.
- W3006242327 hasConcept C196795494 @default.
- W3006242327 hasConcept C20518536 @default.
- W3006242327 hasConcept C2776415932 @default.
- W3006242327 hasConcept C2777609662 @default.
- W3006242327 hasConcept C2778334475 @default.
- W3006242327 hasConcept C2780775167 @default.
- W3006242327 hasConcept C28328180 @default.
- W3006242327 hasConcept C502942594 @default.
- W3006242327 hasConcept C54009773 @default.
- W3006242327 hasConcept C54355233 @default.
- W3006242327 hasConcept C55493867 @default.
- W3006242327 hasConcept C81885089 @default.
- W3006242327 hasConcept C86554907 @default.
- W3006242327 hasConcept C86803240 @default.
- W3006242327 hasConcept C95444343 @default.
- W3006242327 hasConceptScore W3006242327C104317684 @default.