FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006256186> ?p ?o ?g. }

• W3006256186 endingPage "163" @default.
• W3006256186 startingPage "163" @default.
• W3006256186 abstract "In the current study, diethylene glycol monoethyl ether-mediated microemulsions were combined with microneedles for enhanced transdermal aconitine delivery. The oil-in-water microemulsion increasedaconitine solubility and enhanced transdermal drug delivery and assistance with metal microneedles enhanced permeation of the aconitine-loaded microemulsion. Carried by the microemulsion, the in vitro permeability of aconitine was significantly enhanced, and further improved using microneedles. In vivo microdialysis revealed that the subcutaneous local drug concentration reached a high level within 30 min and remained relatively consistent to the end of the experimental period. AUC0-t of the microemulsion group was significantly higher than that of the aqueous solution group, and the microemulsion combined with microneedles group achieved the highest AUC0-t among the tested groups. The microemulsion and microdialysis probe also showed good biocompatibility with skin tissue. The microemulsion could be internalized by HaCaT and CCC-ESF-1 cells via lysosomes. The in vitro cytotoxicity of aconitine toward skin cells was reduced via encapsulation by microemulsion, and the prepared microemulsion developed no skin irritation. Hence, transdermal aconitine delivery and drug biosafety were effectively improved by loading into the microemulsion and assisting with microneedles, and in vivo microdialysis technique is suitable for realtime monitoring of transdermal drug delivery with microemulsion-based drug vehicles." @default.
• W3006256186 created "2020-02-24" @default.
• W3006256186 creator A5000292141 @default.
• W3006256186 creator A5005322043 @default.
• W3006256186 creator A5018331661 @default.
• W3006256186 creator A5044298582 @default.
• W3006256186 creator A5074014325 @default.
• W3006256186 creator A5076381011 @default.
• W3006256186 creator A5089113644 @default.
• W3006256186 date "2020-02-17" @default.
• W3006256186 modified "2023-09-26" @default.
• W3006256186 title "Improved Biosafety and Transdermal Delivery of Aconitine via Diethylene Glycol Monoethyl Ether-Mediated Microemulsion Assisted with Microneedles" @default.
• W3006256186 cites W1006649906 @default.
• W3006256186 cites W1527622642 @default.
• W3006256186 cites W1963641308 @default.
• W3006256186 cites W1964501217 @default.
• W3006256186 cites W1980430908 @default.
• W3006256186 cites W2000734678 @default.
• W3006256186 cites W2001432281 @default.
• W3006256186 cites W2050005850 @default.
• W3006256186 cites W2063693238 @default.
• W3006256186 cites W2300849179 @default.
• W3006256186 cites W2407092926 @default.
• W3006256186 cites W2464984979 @default.
• W3006256186 cites W2519456377 @default.
• W3006256186 cites W2783491141 @default.
• W3006256186 cites W2869163813 @default.
• W3006256186 cites W2890002806 @default.
• W3006256186 cites W2896918429 @default.
• W3006256186 cites W2901388436 @default.
• W3006256186 cites W2911958195 @default.
• W3006256186 cites W2945501476 @default.
• W3006256186 cites W2948571697 @default.
• W3006256186 cites W2954144414 @default.
• W3006256186 cites W2955688288 @default.
• W3006256186 cites W2963201381 @default.
• W3006256186 cites W2972057731 @default.
• W3006256186 cites W2975657798 @default.
• W3006256186 cites W2984747528 @default.
• W3006256186 cites W2987413771 @default.
• W3006256186 cites W2992794111 @default.
• W3006256186 cites W2995869919 @default.
• W3006256186 doi "https://doi.org/10.3390/pharmaceutics12020163" @default.
• W3006256186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7076442" @default.
• W3006256186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32079146" @default.
• W3006256186 hasPublicationYear "2020" @default.
• W3006256186 type Work @default.
• W3006256186 sameAs 3006256186 @default.
• W3006256186 citedByCount "12" @default.
• W3006256186 countsByYear W30062561862020 @default.
• W3006256186 countsByYear W30062561862021 @default.
• W3006256186 countsByYear W30062561862022 @default.
• W3006256186 countsByYear W30062561862023 @default.
• W3006256186 crossrefType "journal-article" @default.
• W3006256186 hasAuthorship W3006256186A5000292141 @default.
• W3006256186 hasAuthorship W3006256186A5005322043 @default.
• W3006256186 hasAuthorship W3006256186A5018331661 @default.
• W3006256186 hasAuthorship W3006256186A5044298582 @default.
• W3006256186 hasAuthorship W3006256186A5074014325 @default.
• W3006256186 hasAuthorship W3006256186A5076381011 @default.
• W3006256186 hasAuthorship W3006256186A5089113644 @default.
• W3006256186 hasBestOaLocation W30062561861 @default.
• W3006256186 hasConcept C13245373 @default.
• W3006256186 hasConcept C150903083 @default.
• W3006256186 hasConcept C178790620 @default.
• W3006256186 hasConcept C185592680 @default.
• W3006256186 hasConcept C190119865 @default.
• W3006256186 hasConcept C192562407 @default.
• W3006256186 hasConcept C205679159 @default.
• W3006256186 hasConcept C207001950 @default.
• W3006256186 hasConcept C2777547430 @default.
• W3006256186 hasConcept C2779820397 @default.
• W3006256186 hasConcept C28406088 @default.
• W3006256186 hasConcept C43617362 @default.
• W3006256186 hasConcept C50156730 @default.
• W3006256186 hasConcept C55493867 @default.
• W3006256186 hasConcept C58226133 @default.
• W3006256186 hasConcept C71924100 @default.
• W3006256186 hasConcept C86803240 @default.
• W3006256186 hasConcept C98274493 @default.
• W3006256186 hasConceptScore W3006256186C13245373 @default.
• W3006256186 hasConceptScore W3006256186C150903083 @default.
• W3006256186 hasConceptScore W3006256186C178790620 @default.
• W3006256186 hasConceptScore W3006256186C185592680 @default.
• W3006256186 hasConceptScore W3006256186C190119865 @default.
• W3006256186 hasConceptScore W3006256186C192562407 @default.
• W3006256186 hasConceptScore W3006256186C205679159 @default.
• W3006256186 hasConceptScore W3006256186C207001950 @default.
• W3006256186 hasConceptScore W3006256186C2777547430 @default.
• W3006256186 hasConceptScore W3006256186C2779820397 @default.
• W3006256186 hasConceptScore W3006256186C28406088 @default.
• W3006256186 hasConceptScore W3006256186C43617362 @default.
• W3006256186 hasConceptScore W3006256186C50156730 @default.
• W3006256186 hasConceptScore W3006256186C55493867 @default.
• W3006256186 hasConceptScore W3006256186C58226133 @default.
• W3006256186 hasConceptScore W3006256186C71924100 @default.
• W3006256186 hasConceptScore W3006256186C86803240 @default.
• W3006256186 hasConceptScore W3006256186C98274493 @default.

• next