FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006319673> ?p ?o ?g. }

• W3006319673 endingPage "36" @default.
• W3006319673 startingPage "23" @default.
• W3006319673 abstract "Background: Loss of immune homeostasis to enteric pathogens is considered to be involved in the pathogenesis of ulcerative colitis (UC), and regulatory T cells (Tregs) are key for this immune homeostasis. Helios exhibits an important effect on regulating the suppressive function of Tregs. Epstein–Barr virus (EBV) is more commonly detected in UC. However, whether there is an association between EBV infection and Helios+Tregs and its impact on disease activity of UC remain unclear. We aimed to explore the clinical significance of Helios+Tregs and their potential association with EBV infection in UC.Methods: Seventy-six UC patients and 38 controls were consecutively enrolled. Helios+FoxP3+Tregs were analyzed using flow cytometry and compared among groups. Eight active UC patients treated with 5-aminosalicylic acid were followed up. Correlation analyses were conducted between Helios+FoxP3+Tregs and disease activity indicators. In addition, EBV viral loads in the mucosal lesion were quantified in active UC by quantitative polymerase chain reaction and were comprehensively analyzed in subgroups of different disease severity, and their associations with Helios+FoxP3+Tregs were also analyzed.Results: Helios+FoxP3+Tregs were significantly decreased in active UC and were inversely correlated with serum C-reactive protein and Mayo score. Moreover, we observed the recovery of Helios+FoxP3+Tregs in followed-up active UC achieving remission after treatment. EBV loads were higher in active UC, and levels of Helios+FoxP3+Tregs in the EBV-positive subgroup were lower than the EBV-negative subgroup in moderate and severe active patients. Most importantly, we found that Helios+FoxP3+Tregs were significantly negatively correlated with EBV viral loads.Conclusion: Helios+FoxP3+Tregs are likely to play a pivotal role in disease activity of UC and may be influenced by EBV infection." @default.
• W3006319673 created "2020-02-24" @default.
• W3006319673 creator A5003360183 @default.
• W3006319673 creator A5022217165 @default.
• W3006319673 creator A5051421670 @default.
• W3006319673 creator A5054860839 @default.
• W3006319673 creator A5056446917 @default.
• W3006319673 creator A5080191032 @default.
• W3006319673 date "2020-02-11" @default.
• W3006319673 modified "2023-10-05" @default.
• W3006319673 title "Infection of Epstein–Barr Virus is Associated with the Decrease of Helios⁺FoxP3⁺Regulatory T Cells in Active Ulcerative Colitis Patients" @default.
• W3006319673 cites W1518295571 @default.
• W3006319673 cites W1753039879 @default.
• W3006319673 cites W1979594892 @default.
• W3006319673 cites W2002964844 @default.
• W3006319673 cites W2025065287 @default.
• W3006319673 cites W2034082915 @default.
• W3006319673 cites W2056629400 @default.
• W3006319673 cites W2059834480 @default.
• W3006319673 cites W2060185417 @default.
• W3006319673 cites W2078621117 @default.
• W3006319673 cites W2102579193 @default.
• W3006319673 cites W2129961630 @default.
• W3006319673 cites W2140612321 @default.
• W3006319673 cites W2142265145 @default.
• W3006319673 cites W2145706989 @default.
• W3006319673 cites W2151088711 @default.
• W3006319673 cites W2151280055 @default.
• W3006319673 cites W2260651029 @default.
• W3006319673 cites W2320873223 @default.
• W3006319673 cites W2337534061 @default.
• W3006319673 cites W2512116127 @default.
• W3006319673 cites W2513424398 @default.
• W3006319673 cites W2626092737 @default.
• W3006319673 cites W2751466910 @default.
• W3006319673 cites W2766888112 @default.
• W3006319673 cites W2805331522 @default.
• W3006319673 cites W2805935255 @default.
• W3006319673 cites W2807141106 @default.
• W3006319673 cites W2809354043 @default.
• W3006319673 cites W2886652351 @default.
• W3006319673 cites W2889972155 @default.
• W3006319673 cites W2902930000 @default.
• W3006319673 cites W2913753644 @default.
• W3006319673 cites W2934446645 @default.
• W3006319673 cites W2946660621 @default.
• W3006319673 cites W2951514370 @default.
• W3006319673 cites W4230633180 @default.
• W3006319673 cites W2034020143 @default.
• W3006319673 doi "https://doi.org/10.1080/08820139.2020.1723021" @default.
• W3006319673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32046542" @default.
• W3006319673 hasPublicationYear "2020" @default.
• W3006319673 type Work @default.
• W3006319673 sameAs 3006319673 @default.
• W3006319673 citedByCount "4" @default.
• W3006319673 countsByYear W30063196732020 @default.
• W3006319673 countsByYear W30063196732021 @default.
• W3006319673 countsByYear W30063196732022 @default.
• W3006319673 crossrefType "journal-article" @default.
• W3006319673 hasAuthorship W3006319673A5003360183 @default.
• W3006319673 hasAuthorship W3006319673A5022217165 @default.
• W3006319673 hasAuthorship W3006319673A5051421670 @default.
• W3006319673 hasAuthorship W3006319673A5054860839 @default.
• W3006319673 hasAuthorship W3006319673A5056446917 @default.
• W3006319673 hasAuthorship W3006319673A5080191032 @default.
• W3006319673 hasBestOaLocation W30063196732 @default.
• W3006319673 hasConcept C126322002 @default.
• W3006319673 hasConcept C203014093 @default.
• W3006319673 hasConcept C2522874641 @default.
• W3006319673 hasConcept C2776090121 @default.
• W3006319673 hasConcept C2778296632 @default.
• W3006319673 hasConcept C2779134260 @default.
• W3006319673 hasConcept C2779727006 @default.
• W3006319673 hasConcept C2780479503 @default.
• W3006319673 hasConcept C2780942790 @default.
• W3006319673 hasConcept C71924100 @default.
• W3006319673 hasConcept C79484868 @default.
• W3006319673 hasConcept C8891405 @default.
• W3006319673 hasConcept C90924648 @default.
• W3006319673 hasConceptScore W3006319673C126322002 @default.
• W3006319673 hasConceptScore W3006319673C203014093 @default.
• W3006319673 hasConceptScore W3006319673C2522874641 @default.
• W3006319673 hasConceptScore W3006319673C2776090121 @default.
• W3006319673 hasConceptScore W3006319673C2778296632 @default.
• W3006319673 hasConceptScore W3006319673C2779134260 @default.
• W3006319673 hasConceptScore W3006319673C2779727006 @default.
• W3006319673 hasConceptScore W3006319673C2780479503 @default.
• W3006319673 hasConceptScore W3006319673C2780942790 @default.
• W3006319673 hasConceptScore W3006319673C71924100 @default.
• W3006319673 hasConceptScore W3006319673C79484868 @default.
• W3006319673 hasConceptScore W3006319673C8891405 @default.
• W3006319673 hasConceptScore W3006319673C90924648 @default.
• W3006319673 hasFunder F4320306076 @default.
• W3006319673 hasFunder F4320321001 @default.
• W3006319673 hasFunder F4320324787 @default.
• W3006319673 hasIssue "1" @default.
• W3006319673 hasLocation W30063196731 @default.
• W3006319673 hasLocation W30063196732 @default.

• next