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• W3006384804 startingPage "1862" @default.
• W3006384804 abstract "Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate on the variable 1 (V1) domain of Env gp120. We demonstrate the presence of this O-glycosylation both on virions and on gp120 expressed as a secreted protein. Further, we establish that these O-linked glycans can confer a more than 1,000-fold decrease in neutralization sensitivity (IC50) to V3-glycan broadly neutralizing antibodies. These findings uncover a structural modification to the HIV-1 Env and suggest a functional role in promoting viral escape from one category of broadly neutralizing antibodies." @default.
• W3006384804 created "2020-02-24" @default.
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• W3006384804 date "2020-02-01" @default.
• W3006384804 modified "2023-10-10" @default.
• W3006384804 title "Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies" @default.
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• W3006384804 doi "https://doi.org/10.1016/j.celrep.2020.01.056" @default.
• W3006384804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7904042" @default.
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