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• W3006389909 abstract "Lipopolysaccharide (LPS) is an endotoxin that prompts neuroinflammation and initiates neurodegenerative disorders. Exosome is a recent therapeutic agent for many diseases such as neurological diseases. This study aimed to evaluate the potential protective role of bone marrow mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were taken and processed for histological and immunohistochemical analysis. Morphometrical studies and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The mean number of Purkinje cells was significantly (P<0.01) decreased, while glial fibrillary acidic protein (GFAP) immunoexpression was significantly increased in the neuroglial cells. Ultrastructural examination showed shrunken Purkinje cells with irregular nuclei and disrupted mitochondria. Group III showed improvement of most of the changes mentioned previously. EXs therapy is a promising neuroprotective tool for treatment of LPS-induced neuroinflammation." @default.
• W3006389909 created "2020-02-24" @default.
• W3006389909 creator A5022174187 @default.
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• W3006389909 date "2020-02-10" @default.
• W3006389909 modified "2023-10-16" @default.
• W3006389909 title "The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study" @default.
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• W3006389909 doi "https://doi.org/10.1080/01913123.2020.1726547" @default.
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