Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006402179> ?p ?o ?g. }
- W3006402179 endingPage "114153" @default.
- W3006402179 startingPage "114153" @default.
- W3006402179 abstract "F-53B and PFOS are two per- and polyfluoroalkyl substances (PFASs) widely utilized in the metal plating industry as mist suppressants. Recent epidemiological studies have linked PFASs to cardiovascular diseases and alterations in heart geometry. However, we still have limited understanding of the effects of F-53B and PFOS on the developing heart. In this study, we employed a human embryonic stem cell (hESC)-based cardiac differentiation system and whole transcriptomics analyses to evaluate the potential developmental cardiac toxicity of F-53B and PFOS. We utilized F-53B and PFOS concentrations of 0.1-60 μM, covering the levels detected in human blood samples. We demonstrated that both F-53B and PFOS inhibited cardiac differentiation and promoted epicardial specification via upregulation of the WNT signaling pathway. Most importantly, the effects of F-53B were more robust than those of PFOS. This was because F-53B treatment disrupted the expression of more genes and led to lower cardiac differentiation efficiency. These findings imply that F-53B may not be a safe replacement for PFOS." @default.
- W3006402179 created "2020-02-24" @default.
- W3006402179 creator A5003344867 @default.
- W3006402179 creator A5003916408 @default.
- W3006402179 creator A5015917983 @default.
- W3006402179 creator A5029834873 @default.
- W3006402179 creator A5046109998 @default.
- W3006402179 creator A5069834233 @default.
- W3006402179 creator A5080448919 @default.
- W3006402179 date "2020-06-01" @default.
- W3006402179 modified "2023-10-12" @default.
- W3006402179 title "F–53B and PFOS treatments skew human embryonic stem cell in vitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway" @default.
- W3006402179 cites W1195941168 @default.
- W3006402179 cites W1848206716 @default.
- W3006402179 cites W1955467086 @default.
- W3006402179 cites W2001219281 @default.
- W3006402179 cites W2004809711 @default.
- W3006402179 cites W2005460301 @default.
- W3006402179 cites W2010732217 @default.
- W3006402179 cites W2012517517 @default.
- W3006402179 cites W2014995450 @default.
- W3006402179 cites W2022041605 @default.
- W3006402179 cites W2024343903 @default.
- W3006402179 cites W2045860850 @default.
- W3006402179 cites W2049414564 @default.
- W3006402179 cites W2055576275 @default.
- W3006402179 cites W2061678904 @default.
- W3006402179 cites W2066390373 @default.
- W3006402179 cites W2077095632 @default.
- W3006402179 cites W2077774531 @default.
- W3006402179 cites W2105379763 @default.
- W3006402179 cites W2125775820 @default.
- W3006402179 cites W2143268985 @default.
- W3006402179 cites W2146117781 @default.
- W3006402179 cites W2153158580 @default.
- W3006402179 cites W2173828297 @default.
- W3006402179 cites W2210678775 @default.
- W3006402179 cites W2226224971 @default.
- W3006402179 cites W2259233223 @default.
- W3006402179 cites W2263492392 @default.
- W3006402179 cites W2322346801 @default.
- W3006402179 cites W2334573654 @default.
- W3006402179 cites W2559332941 @default.
- W3006402179 cites W2560311421 @default.
- W3006402179 cites W2560702716 @default.
- W3006402179 cites W2562899729 @default.
- W3006402179 cites W2585884657 @default.
- W3006402179 cites W2592161594 @default.
- W3006402179 cites W2605488394 @default.
- W3006402179 cites W2731625185 @default.
- W3006402179 cites W2737585453 @default.
- W3006402179 cites W2748755100 @default.
- W3006402179 cites W2753879044 @default.
- W3006402179 cites W2771283354 @default.
- W3006402179 cites W2795622812 @default.
- W3006402179 cites W2795896501 @default.
- W3006402179 cites W2801936321 @default.
- W3006402179 cites W2804398466 @default.
- W3006402179 cites W2805053350 @default.
- W3006402179 cites W2808756851 @default.
- W3006402179 cites W2809782264 @default.
- W3006402179 cites W2883572790 @default.
- W3006402179 cites W2887188343 @default.
- W3006402179 cites W2889376059 @default.
- W3006402179 cites W2890200938 @default.
- W3006402179 cites W2894219029 @default.
- W3006402179 cites W2896434302 @default.
- W3006402179 cites W2897810688 @default.
- W3006402179 cites W2913575462 @default.
- W3006402179 cites W2918818254 @default.
- W3006402179 cites W44429629 @default.
- W3006402179 cites W807459879 @default.
- W3006402179 doi "https://doi.org/10.1016/j.envpol.2020.114153" @default.
- W3006402179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32088431" @default.
- W3006402179 hasPublicationYear "2020" @default.
- W3006402179 type Work @default.
- W3006402179 sameAs 3006402179 @default.
- W3006402179 citedByCount "23" @default.
- W3006402179 countsByYear W30064021792020 @default.
- W3006402179 countsByYear W30064021792021 @default.
- W3006402179 countsByYear W30064021792022 @default.
- W3006402179 countsByYear W30064021792023 @default.
- W3006402179 crossrefType "journal-article" @default.
- W3006402179 hasAuthorship W3006402179A5003344867 @default.
- W3006402179 hasAuthorship W3006402179A5003916408 @default.
- W3006402179 hasAuthorship W3006402179A5015917983 @default.
- W3006402179 hasAuthorship W3006402179A5029834873 @default.
- W3006402179 hasAuthorship W3006402179A5046109998 @default.
- W3006402179 hasAuthorship W3006402179A5069834233 @default.
- W3006402179 hasAuthorship W3006402179A5080448919 @default.
- W3006402179 hasConcept C104317684 @default.
- W3006402179 hasConcept C126322002 @default.
- W3006402179 hasConcept C127561419 @default.
- W3006402179 hasConcept C137620995 @default.
- W3006402179 hasConcept C145103041 @default.
- W3006402179 hasConcept C148738053 @default.
- W3006402179 hasConcept C150194340 @default.
- W3006402179 hasConcept C162317418 @default.