FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006404080> ?p ?o ?g. }

• W3006404080 endingPage "128" @default.
• W3006404080 startingPage "120" @default.
• W3006404080 abstract "The use of DNA-encoded libraries has emerged as a powerful hit generation technology. Combining the power of combinatorial chemistry to enumerate large compound collections with the efficiency of affinity selection in pools, the methodology makes it possible to interrogate vast chemical space against biological targets of pharmaceutical relevance. Thus, the chemical transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format." @default.
• W3006404080 created "2020-02-24" @default.
• W3006404080 creator A5019066295 @default.
• W3006404080 creator A5030776953 @default.
• W3006404080 creator A5041266160 @default.
• W3006404080 creator A5065156364 @default.
• W3006404080 creator A5071067004 @default.
• W3006404080 creator A5077916667 @default.
• W3006404080 creator A5087130118 @default.
• W3006404080 date "2020-02-10" @default.
• W3006404080 modified "2023-10-17" @default.
• W3006404080 title "An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis" @default.
• W3006404080 cites W1160365437 @default.
• W3006404080 cites W1554936245 @default.
• W3006404080 cites W1608833148 @default.
• W3006404080 cites W1964430808 @default.
• W3006404080 cites W1968753037 @default.
• W3006404080 cites W1977052508 @default.
• W3006404080 cites W1989292538 @default.
• W3006404080 cites W1996941025 @default.
• W3006404080 cites W2014367004 @default.
• W3006404080 cites W2015409669 @default.
• W3006404080 cites W2017423606 @default.
• W3006404080 cites W2054204077 @default.
• W3006404080 cites W2060265722 @default.
• W3006404080 cites W2074274985 @default.
• W3006404080 cites W2096095251 @default.
• W3006404080 cites W2120738140 @default.
• W3006404080 cites W2154603021 @default.
• W3006404080 cites W2166602500 @default.
• W3006404080 cites W2299985318 @default.
• W3006404080 cites W2321524437 @default.
• W3006404080 cites W2322365255 @default.
• W3006404080 cites W2322478754 @default.
• W3006404080 cites W2334494814 @default.
• W3006404080 cites W2342256030 @default.
• W3006404080 cites W2404493308 @default.
• W3006404080 cites W2480712017 @default.
• W3006404080 cites W2503131032 @default.
• W3006404080 cites W2508142674 @default.
• W3006404080 cites W2560300306 @default.
• W3006404080 cites W2560677837 @default.
• W3006404080 cites W2592265713 @default.
• W3006404080 cites W2732615433 @default.
• W3006404080 cites W2781840561 @default.
• W3006404080 cites W2795942127 @default.
• W3006404080 cites W2803083648 @default.
• W3006404080 cites W2803200384 @default.
• W3006404080 cites W2810724953 @default.
• W3006404080 cites W2885400948 @default.
• W3006404080 cites W2886487481 @default.
• W3006404080 cites W2896829551 @default.
• W3006404080 cites W2908569837 @default.
• W3006404080 cites W2913261199 @default.
• W3006404080 cites W2914184638 @default.
• W3006404080 cites W2937482900 @default.
• W3006404080 cites W2941297394 @default.
• W3006404080 cites W2947079937 @default.
• W3006404080 cites W2969846984 @default.
• W3006404080 cites W2978690934 @default.
• W3006404080 cites W589574422 @default.
• W3006404080 doi "https://doi.org/10.1021/acscombsci.9b00164" @default.
• W3006404080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32040908" @default.
• W3006404080 hasPublicationYear "2020" @default.
• W3006404080 type Work @default.
• W3006404080 sameAs 3006404080 @default.
• W3006404080 citedByCount "36" @default.
• W3006404080 countsByYear W30064040802020 @default.
• W3006404080 countsByYear W30064040802021 @default.
• W3006404080 countsByYear W30064040802022 @default.
• W3006404080 countsByYear W30064040802023 @default.
• W3006404080 crossrefType "journal-article" @default.
• W3006404080 hasAuthorship W3006404080A5019066295 @default.
• W3006404080 hasAuthorship W3006404080A5030776953 @default.
• W3006404080 hasAuthorship W3006404080A5041266160 @default.
• W3006404080 hasAuthorship W3006404080A5065156364 @default.
• W3006404080 hasAuthorship W3006404080A5071067004 @default.
• W3006404080 hasAuthorship W3006404080A5077916667 @default.
• W3006404080 hasAuthorship W3006404080A5087130118 @default.
• W3006404080 hasBestOaLocation W30064040801 @default.
• W3006404080 hasConcept C112613896 @default.
• W3006404080 hasConcept C15920480 @default.
• W3006404080 hasConcept C178790620 @default.
• W3006404080 hasConcept C183882617 @default.
• W3006404080 hasConcept C185592680 @default.
• W3006404080 hasConcept C187714232 @default.
• W3006404080 hasConcept C21951064 @default.
• W3006404080 hasConcept C521977710 @default.
• W3006404080 hasConcept C552990157 @default.
• W3006404080 hasConcept C55493867 @default.
• W3006404080 hasConcept C67407626 @default.
• W3006404080 hasConceptScore W3006404080C112613896 @default.
• W3006404080 hasConceptScore W3006404080C15920480 @default.
• W3006404080 hasConceptScore W3006404080C178790620 @default.
• W3006404080 hasConceptScore W3006404080C183882617 @default.
• W3006404080 hasConceptScore W3006404080C185592680 @default.
• W3006404080 hasConceptScore W3006404080C187714232 @default.
• W3006404080 hasConceptScore W3006404080C21951064 @default.

• next