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- W3006411511 endingPage "455" @default.
- W3006411511 startingPage "439" @default.
- W3006411511 abstract "Dysregulated metabolism is one of the hallmarks of cancer. Under normal physiological conditions, ATP is primarily generated by oxidative phosphorylation. Cancers commonly undergo a dramatic shift toward glycolysis, despite the presence of oxygen. This phenomenon is known as the Warburg effect, and requires the activity of LDHA. LDHA converts pyruvate to lactate in the final step of glycolysis and is often upregulated in cancer. LDHA inhibitors present a promising therapeutic option, as LDHA blockade leads to apoptosis in cancer cells. Despite this, existing LDHA inhibitors have shown limited clinical efficacy. Here, we review recent progress in LDHA structure, function and regulation as well as strategies to target this critical enzyme." @default.
- W3006411511 created "2020-02-24" @default.
- W3006411511 creator A5007706410 @default.
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- W3006411511 creator A5058621466 @default.
- W3006411511 creator A5083807847 @default.
- W3006411511 creator A5087877770 @default.
- W3006411511 date "2020-03-01" @default.
- W3006411511 modified "2023-10-02" @default.
- W3006411511 title "Structural and functional regulation of lactate dehydrogenase-A in cancer" @default.
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