Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006414475> ?p ?o ?g. }
- W3006414475 endingPage "100523" @default.
- W3006414475 startingPage "100523" @default.
- W3006414475 abstract "Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that can affect individuals across the entire lifespan. Dysregulations of the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of this disorder. Previous studies have used proton magnetic resonance spectroscopy (1H-MRS) to detect neurometabolic abnormalities in the CSTC circuits of OCD patients. In this study, we systematically reviewed studies that used 3 Tesla 1H-MRS to investigate neurometabolite concentrations in OCD patients versus healthy controls. We also reviewed associations between neurometabolite concentrations and symptom severity and the effect of treatment. Out of the 1161 articles that were identified by our literature search, 22 articles met our inclusion criteria for this review. Most studies did not demonstrate any neurometabolite abnormalities in OCD patients compared with controls, but some mixed results were found depending on the region of interest. The most consistent findings showed lower gamma aminobutyric acid (GABA) concentrations in the rostral anterior cingulate cortex (rACC) and higher choline concentrations in the thalamus of adult OCD patients compared to controls. Glutamate concentrations decreased after treatment in one study, but not in another. Some studies reported a correlation between neurometabolite concentrations and symptom severity, but the direction of this relation remains unclear and might be dependent on the brain region. These results do not provide strong evidence for OCD-related neurometabolite abnormalities. Because of the inconsistent results and the large heterogeneity between studies, more research is needed to investigate the exact role of neurochemistry in OCD and the utility of 1H-MRS to study it." @default.
- W3006414475 created "2020-02-24" @default.
- W3006414475 creator A5008293806 @default.
- W3006414475 creator A5016766601 @default.
- W3006414475 creator A5050362424 @default.
- W3006414475 creator A5058032050 @default.
- W3006414475 creator A5070997624 @default.
- W3006414475 date "2020-04-01" @default.
- W3006414475 modified "2023-10-12" @default.
- W3006414475 title "Little evidence for neurometabolite alterations in obsessive-compulsive disorder - A systematic review of magnetic resonance spectroscopy studies at 3 Tesla" @default.
- W3006414475 cites W1497537994 @default.
- W3006414475 cites W1638218062 @default.
- W3006414475 cites W1731455094 @default.
- W3006414475 cites W1869803090 @default.
- W3006414475 cites W1965264828 @default.
- W3006414475 cites W1966947940 @default.
- W3006414475 cites W1968419455 @default.
- W3006414475 cites W1970068884 @default.
- W3006414475 cites W2000350151 @default.
- W3006414475 cites W2005930646 @default.
- W3006414475 cites W2009597582 @default.
- W3006414475 cites W2011477622 @default.
- W3006414475 cites W2012440798 @default.
- W3006414475 cites W2016063613 @default.
- W3006414475 cites W2017502608 @default.
- W3006414475 cites W2020485031 @default.
- W3006414475 cites W2022716509 @default.
- W3006414475 cites W2024341364 @default.
- W3006414475 cites W2024753688 @default.
- W3006414475 cites W2036459306 @default.
- W3006414475 cites W2039042355 @default.
- W3006414475 cites W2040241585 @default.
- W3006414475 cites W2042514413 @default.
- W3006414475 cites W2047768580 @default.
- W3006414475 cites W2047801483 @default.
- W3006414475 cites W2050239239 @default.
- W3006414475 cites W2051607590 @default.
- W3006414475 cites W2053626793 @default.
- W3006414475 cites W2057120528 @default.
- W3006414475 cites W2060368209 @default.
- W3006414475 cites W2062056354 @default.
- W3006414475 cites W2062657498 @default.
- W3006414475 cites W2064334410 @default.
- W3006414475 cites W2065020592 @default.
- W3006414475 cites W2073446781 @default.
- W3006414475 cites W2074818912 @default.
- W3006414475 cites W2075274642 @default.
- W3006414475 cites W2076097313 @default.
- W3006414475 cites W2076682630 @default.
- W3006414475 cites W2078695322 @default.
- W3006414475 cites W2079997496 @default.
- W3006414475 cites W2083331867 @default.
- W3006414475 cites W2088382955 @default.
- W3006414475 cites W2092381672 @default.
- W3006414475 cites W2094818785 @default.
- W3006414475 cites W2097272243 @default.
- W3006414475 cites W2100861230 @default.
- W3006414475 cites W2101660242 @default.
- W3006414475 cites W2102462556 @default.
- W3006414475 cites W2109125813 @default.
- W3006414475 cites W2122215269 @default.
- W3006414475 cites W2123822033 @default.
- W3006414475 cites W2129767413 @default.
- W3006414475 cites W2142016029 @default.
- W3006414475 cites W2143828201 @default.
- W3006414475 cites W2147527277 @default.
- W3006414475 cites W2402775250 @default.
- W3006414475 cites W2517818012 @default.
- W3006414475 cites W2536618353 @default.
- W3006414475 cites W2552463237 @default.
- W3006414475 cites W2569564747 @default.
- W3006414475 cites W2606502369 @default.
- W3006414475 cites W2739834351 @default.
- W3006414475 cites W2756204199 @default.
- W3006414475 cites W2768318677 @default.
- W3006414475 cites W2768417013 @default.
- W3006414475 cites W2803021597 @default.
- W3006414475 cites W2965887024 @default.
- W3006414475 cites W4239154108 @default.
- W3006414475 doi "https://doi.org/10.1016/j.jocrd.2020.100523" @default.
- W3006414475 hasPublicationYear "2020" @default.
- W3006414475 type Work @default.
- W3006414475 sameAs 3006414475 @default.
- W3006414475 citedByCount "4" @default.
- W3006414475 countsByYear W30064144752021 @default.
- W3006414475 countsByYear W30064144752023 @default.
- W3006414475 crossrefType "journal-article" @default.
- W3006414475 hasAuthorship W3006414475A5008293806 @default.
- W3006414475 hasAuthorship W3006414475A5016766601 @default.
- W3006414475 hasAuthorship W3006414475A5050362424 @default.
- W3006414475 hasAuthorship W3006414475A5058032050 @default.
- W3006414475 hasAuthorship W3006414475A5070997624 @default.
- W3006414475 hasConcept C10162356 @default.
- W3006414475 hasConcept C118552586 @default.
- W3006414475 hasConcept C121332964 @default.
- W3006414475 hasConcept C126322002 @default.
- W3006414475 hasConcept C126838900 @default.
- W3006414475 hasConcept C143409427 @default.