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- W3006482012 abstract "Integrating different therapies into a single nanoplatform has shown great potential for synergistic anti-tumor therapy. In this work, we fabricated the graphene oxide (GO)-based nanosheets loaded with chemotherapeutic drug 5-fluorouracil (5-FU) and modified with GE11, which is an efficient ligand for epidermal growth factor receptor (EGFR). The nanocomposite system 5-FU/GO-PEG-GE11 was found to transfer 5-FU into EGFR-overexpressing HCT-116 cells effectively. The oxidation of glutathione in the tumor cells was found to be accelerated and then destroy the intracellular redox balance after irradiation. The 5-FU/GO-PEG-GE11 nanocomposites exhibited an enhanced synergistic anti-tumor efficacy both in vitro and in vivo. Tumor inhibition rate was 90 % in subcutaneous colorectal cancer (CRC) bearing mouse model. The GO-based nanocomposites serve as a versatile platform integrated of PTT and chemotherapy with EGFR-targeting ability, which hold great promise for CRC treatment." @default.
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- W3006482012 date "2020-05-01" @default.
- W3006482012 modified "2023-10-15" @default.
- W3006482012 title "Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer" @default.
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- W3006482012 doi "https://doi.org/10.1016/j.colsurfa.2020.124585" @default.
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