Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006519311> ?p ?o ?g. }
- W3006519311 abstract "Abstract Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase in PD-1 + CD44 high CD4 T cells as well as CD95 + GL7 + germinal center B cells, indicating that the long-term circadian misalignment exacerbates immune senescence and consequent chronic inflammation. Our results underscore immune homeostasis as a pivotal interventional target against clock-related disorders." @default.
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- W3006519311 date "2020-02-13" @default.
- W3006519311 modified "2023-10-18" @default.
- W3006519311 title "Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice" @default.
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- W3006519311 cites W1993818414 @default.
- W3006519311 cites W1999298001 @default.
- W3006519311 cites W2009077913 @default.
- W3006519311 cites W2014313900 @default.
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- W3006519311 cites W2014699371 @default.
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- W3006519311 cites W2179438025 @default.
- W3006519311 cites W2342969444 @default.
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- W3006519311 doi "https://doi.org/10.1038/s41598-020-59541-y" @default.
- W3006519311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7018741" @default.
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