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- W3006596946 abstract "Twenty-five novel 2,4,6-trisubstituted triazines were synthesized and biologically evaluated. Most of the compounds synthesized showed good antiproliferative activity against HCT-116 and MCF-7. Compounds B18 and B19 showed the best antiproliferative activity. Further study showed B18 and B19 inhibited four phosphoinositide 3-kinase isoforms and mammalian target of rapamycin with good potency. These results demonstrate that 2,4,6-trisubstituted triazines are potentially useful phosphoinositide 3-kinase inhibitors for the development of new anticancer drugs." @default.
- W3006596946 created "2020-02-24" @default.
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- W3006596946 date "2020-02-11" @default.
- W3006596946 modified "2023-10-18" @default.
- W3006596946 title "Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors" @default.
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- W3006596946 doi "https://doi.org/10.1177/1747519820904844" @default.
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