FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006699581> ?p ?o ?g. }

• W3006699581 endingPage "102417" @default.
• W3006699581 startingPage "102417" @default.
• W3006699581 abstract "miR-194-5p and NEAT1 have been reported to be associated with multiple malignancies, but their roles in acute myeloid leukemia (AML) remains not fully understood. Bone marrow samples were collected for monocyte separation. qRT-PCR assay was performed to investigate the expression patterns of NEAT1 and miR-194-5p in AML. CCK-8, soft agar colony formation, flow cytometry and transwell assays were employed to explore the biological functions of NEAT1 or miR-194-5p. Methylation PCR was performed to monitor the methylation of NEAT1. Luciferase reporter assay was subjected to verify the relationship between miR-194-5p and DNMT3A. Immunofluorescence and western blotting were performed to detect the alterations of protein expression. NEAT1 and miR-194-5p were both down-regulated in AML. Overexpression of either NEAT1 or miR-194-5p repressed proliferation, induced apoptosis and restrained migration and invasion of AML cells. There was a negative correlation between NEAT1 and DNMT3A in AML. Knockdown of DNMT3A dramatically decreased the methylation of NEAT1. Moreover, DNMT3A was identified as a downstream target of miR-194-5p. Furthermore, down-regulation of DNMT3A rescued the impacts on the malignant phenotypes of NEAT1 inhibition by miR-194-5p inhibitor. Altogether, down-regulation of NEAT1 mediated by miR-194-5p/DNMT3A axis promotes AML progression, which might provide therapeutic targets in AML treatment." @default.
• W3006699581 created "2020-03-06" @default.
• W3006699581 creator A5004041644 @default.
• W3006699581 creator A5012378388 @default.
• W3006699581 creator A5021384155 @default.
• W3006699581 creator A5048582579 @default.
• W3006699581 creator A5066928669 @default.
• W3006699581 creator A5087541016 @default.
• W3006699581 date "2020-05-01" @default.
• W3006699581 modified "2023-09-26" @default.
• W3006699581 title "Down-regulation of lncRNA NEAT1 regulated by miR-194-5p/DNMT3A facilitates acute myeloid leukemia" @default.
• W3006699581 cites W1821797507 @default.
• W3006699581 cites W1944231772 @default.
• W3006699581 cites W1977421929 @default.
• W3006699581 cites W2012858030 @default.
• W3006699581 cites W2014946489 @default.
• W3006699581 cites W2039816251 @default.
• W3006699581 cites W2059191987 @default.
• W3006699581 cites W2077863885 @default.
• W3006699581 cites W2087377443 @default.
• W3006699581 cites W2094546718 @default.
• W3006699581 cites W2105349784 @default.
• W3006699581 cites W2116236561 @default.
• W3006699581 cites W2116858301 @default.
• W3006699581 cites W2130727876 @default.
• W3006699581 cites W2142016502 @default.
• W3006699581 cites W2158872718 @default.
• W3006699581 cites W2162674813 @default.
• W3006699581 cites W2170166321 @default.
• W3006699581 cites W2196110459 @default.
• W3006699581 cites W2206368938 @default.
• W3006699581 cites W2291638877 @default.
• W3006699581 cites W2443106611 @default.
• W3006699581 cites W2560322684 @default.
• W3006699581 cites W2613822734 @default.
• W3006699581 cites W2614986146 @default.
• W3006699581 cites W2775670249 @default.
• W3006699581 cites W2783386765 @default.
• W3006699581 cites W2892751335 @default.
• W3006699581 cites W2895999225 @default.
• W3006699581 cites W2897806407 @default.
• W3006699581 cites W4231346141 @default.
• W3006699581 doi "https://doi.org/10.1016/j.bcmd.2020.102417" @default.
• W3006699581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32179410" @default.
• W3006699581 hasPublicationYear "2020" @default.
• W3006699581 type Work @default.
• W3006699581 sameAs 3006699581 @default.
• W3006699581 citedByCount "17" @default.
• W3006699581 countsByYear W30066995812020 @default.
• W3006699581 countsByYear W30066995812021 @default.
• W3006699581 countsByYear W30066995812022 @default.
• W3006699581 countsByYear W30066995812023 @default.
• W3006699581 crossrefType "journal-article" @default.
• W3006699581 hasAuthorship W3006699581A5004041644 @default.
• W3006699581 hasAuthorship W3006699581A5012378388 @default.
• W3006699581 hasAuthorship W3006699581A5021384155 @default.
• W3006699581 hasAuthorship W3006699581A5048582579 @default.
• W3006699581 hasAuthorship W3006699581A5066928669 @default.
• W3006699581 hasAuthorship W3006699581A5087541016 @default.
• W3006699581 hasConcept C104317684 @default.
• W3006699581 hasConcept C127561419 @default.
• W3006699581 hasConcept C150194340 @default.
• W3006699581 hasConcept C153911025 @default.
• W3006699581 hasConcept C173396325 @default.
• W3006699581 hasConcept C190283241 @default.
• W3006699581 hasConcept C190727270 @default.
• W3006699581 hasConcept C203014093 @default.
• W3006699581 hasConcept C2778461978 @default.
• W3006699581 hasConcept C2778729363 @default.
• W3006699581 hasConcept C2779282312 @default.
• W3006699581 hasConcept C2780007613 @default.
• W3006699581 hasConcept C33288867 @default.
• W3006699581 hasConcept C502942594 @default.
• W3006699581 hasConcept C553184892 @default.
• W3006699581 hasConcept C55493867 @default.
• W3006699581 hasConcept C60365752 @default.
• W3006699581 hasConcept C62203573 @default.
• W3006699581 hasConcept C86803240 @default.
• W3006699581 hasConceptScore W3006699581C104317684 @default.
• W3006699581 hasConceptScore W3006699581C127561419 @default.
• W3006699581 hasConceptScore W3006699581C150194340 @default.
• W3006699581 hasConceptScore W3006699581C153911025 @default.
• W3006699581 hasConceptScore W3006699581C173396325 @default.
• W3006699581 hasConceptScore W3006699581C190283241 @default.
• W3006699581 hasConceptScore W3006699581C190727270 @default.
• W3006699581 hasConceptScore W3006699581C203014093 @default.
• W3006699581 hasConceptScore W3006699581C2778461978 @default.
• W3006699581 hasConceptScore W3006699581C2778729363 @default.
• W3006699581 hasConceptScore W3006699581C2779282312 @default.
• W3006699581 hasConceptScore W3006699581C2780007613 @default.
• W3006699581 hasConceptScore W3006699581C33288867 @default.
• W3006699581 hasConceptScore W3006699581C502942594 @default.
• W3006699581 hasConceptScore W3006699581C553184892 @default.
• W3006699581 hasConceptScore W3006699581C55493867 @default.
• W3006699581 hasConceptScore W3006699581C60365752 @default.
• W3006699581 hasConceptScore W3006699581C62203573 @default.
• W3006699581 hasConceptScore W3006699581C86803240 @default.
• W3006699581 hasFunder F4320321001 @default.

• next