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• W3006802019 abstract "Partner and localizer of BRCA2 (PALB2) is vital for homologous recombination (HR) repair in response to DNA double-strand breaks (DSBs). PALB2 functions as a tumor suppressor and participates in the maintenance of genome integrity. In this review, we summarize the current knowledge of the biological roles of the multifaceted PALB2 protein and of its regulation. Moreover, we describe the link between PALB2 pathogenic variants (PVs) and breast cancer predisposition, aggressive clinicopathological features, and adverse clinical prognosis. We also refer to both the opportunities and challenges that the identification of PALB2 PVs provides in breast cancer genetic counseling and precision medicine." @default.
• W3006802019 created "2020-03-06" @default.
• W3006802019 creator A5006044524 @default.
• W3006802019 creator A5012739197 @default.
• W3006802019 creator A5017335541 @default.
• W3006802019 creator A5025489995 @default.
• W3006802019 creator A5040937372 @default.
• W3006802019 creator A5056137294 @default.
• W3006802019 creator A5067803298 @default.
• W3006802019 creator A5089309781 @default.
• W3006802019 date "2020-02-28" @default.
• W3006802019 modified "2023-10-01" @default.
• W3006802019 title "Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management" @default.
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