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- W3006877353 abstract "Introduction/Background Tumor growth is characterized by a modified ratio of apoptotic and mitotic indexes. Purpose of research was to assess the cfDNA levels change during tumor growth and the effect of antitumor drug from group of acetylated cytostatic dioxadet in a model of transplanted ascites ovarian cancer (OC) in female rats. Methodology Tumor was transplanted intraperitoneally to 12-week-old Wistar rats (n=20) by introducing 1×107 tumor cells in 0.5 ml of saline. 48 h after OC inoculation dioxadet at the maximum tolerated dose of 1.5 mg/kg b.w. was injected intraperitoneally to rats (n=10) and saline was injected intraperitoneally to control rats (n=10). The results were evaluated by the increase in median survival (MS) of rats and by the content of cfDNA. Blood from rats was taken from the peripheral vein at intervals of 0, 2, 4, 6 and 8 days after inoculation and EDTA-plasma was separated. The cfDNA content was measured by ELISA assay. Results The blood plasma cfDNA level of rats initially, before OC transplantation, was 1.6±0.33 ng/µl, without changing within 2 days, was significantly higher after 6 days (9.84±3.96 ng/µl, p Conclusion A significant (56%) increase in rat’s life expectancy caused by dioxadet is accompanied by cfDNA level decrease in the 2 days after injection of the drug. Thus, the measurement of cfDNA can be used to assess the effectiveness of the cytostatic effect in the clinic. Disclosure Nothing to disclose." @default.
- W3006877353 created "2020-03-06" @default.
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- W3006877353 date "2019-11-01" @default.
- W3006877353 modified "2023-09-26" @default.
- W3006877353 title "EP1016 Evaluation of the antitumor effect of dioxade on the change in the content of free DNA in the blood" @default.
- W3006877353 doi "https://doi.org/10.1136/ijgc-2019-esgo.1060" @default.
- W3006877353 hasPublicationYear "2019" @default.
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