Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006898322> ?p ?o ?g. }
- W3006898322 endingPage "2598" @default.
- W3006898322 startingPage "2590" @default.
- W3006898322 abstract "The biohybrid polymer membrane (BHM) is a new biomaterial designed for the treatment of soft periodontal tissue defects. We aimed to evaluate the in vitro biocompatibility of the membrane in human gingival fibroblasts and the capability to induce cell adhesion, migration, differentiation and improving the production of the extracellular matrix. BHM and Mucograft® collagen matrix (MCM) membranes were punched into 6 mm diameter round discs and placed in 96-well plates. Human primary gingival fibroblasts were seeded on the membranes or tissue culture plastic (TCP) serving as the control. Cell proliferation/viability and morphology were evaluated after 3, 7, and 14 days of culture by cell counting kit (CCK)-8 assay and scanning electron microscopy, respectively. Additionally, the gene expression of transforming growth factor (TGF)-β1, focal adhesion kinase (FAK), collagen type 1 (Col1), alpha-smooth muscle actin (α-SMA), and fibroblasts growth factor (FGF)-2 was analyzed at 3, 7, and 14 days of culture by qPCR. Cell proliferation on BHM was significantly higher than on MCM and similar to TCP. Gene expression of TGF-β1, FAK, Col1, and α-SMA were significantly increased on BHM compared to TCP at most investigated time points. However, the gene expression of FGF-2 was significantly decreased on BHM at Day 7 and recovered at Day 14 to the levels similar to TCP. The finding of this study showed that BHM is superior for gingival fibroblasts in terms of adhesion, proliferation, and gene expression, suggesting that this membrane may promote the healing of soft periodontal tissue." @default.
- W3006898322 created "2020-03-06" @default.
- W3006898322 creator A5006755143 @default.
- W3006898322 creator A5032773909 @default.
- W3006898322 creator A5036318725 @default.
- W3006898322 creator A5048952889 @default.
- W3006898322 creator A5052636469 @default.
- W3006898322 creator A5053969245 @default.
- W3006898322 creator A5082918256 @default.
- W3006898322 creator A5086569305 @default.
- W3006898322 date "2020-02-25" @default.
- W3006898322 modified "2023-09-29" @default.
- W3006898322 title "In vitro biocompatibility of biohybrid polymers membrane evaluated in human gingival fibroblasts" @default.
- W3006898322 cites W1445488588 @default.
- W3006898322 cites W1486578559 @default.
- W3006898322 cites W1533264109 @default.
- W3006898322 cites W1981568312 @default.
- W3006898322 cites W1982769493 @default.
- W3006898322 cites W1987834227 @default.
- W3006898322 cites W2005289932 @default.
- W3006898322 cites W2009685791 @default.
- W3006898322 cites W2039889108 @default.
- W3006898322 cites W2040015091 @default.
- W3006898322 cites W2046512671 @default.
- W3006898322 cites W2052649367 @default.
- W3006898322 cites W2055324675 @default.
- W3006898322 cites W2056289684 @default.
- W3006898322 cites W2075286866 @default.
- W3006898322 cites W2098916371 @default.
- W3006898322 cites W2112420237 @default.
- W3006898322 cites W2114270638 @default.
- W3006898322 cites W2119102689 @default.
- W3006898322 cites W2142760419 @default.
- W3006898322 cites W2148328620 @default.
- W3006898322 cites W2169853178 @default.
- W3006898322 cites W2261162807 @default.
- W3006898322 cites W2269115977 @default.
- W3006898322 cites W2340461645 @default.
- W3006898322 cites W2493805560 @default.
- W3006898322 cites W2516328293 @default.
- W3006898322 cites W2575475206 @default.
- W3006898322 cites W2618120608 @default.
- W3006898322 cites W2736205691 @default.
- W3006898322 cites W2765195981 @default.
- W3006898322 cites W2768310847 @default.
- W3006898322 cites W2780331906 @default.
- W3006898322 cites W2789127085 @default.
- W3006898322 cites W2791627713 @default.
- W3006898322 cites W2889332058 @default.
- W3006898322 cites W2891079510 @default.
- W3006898322 cites W2898115576 @default.
- W3006898322 cites W2900330183 @default.
- W3006898322 cites W2903371431 @default.
- W3006898322 cites W2903512259 @default.
- W3006898322 cites W2911786443 @default.
- W3006898322 cites W2939085288 @default.
- W3006898322 cites W2941120987 @default.
- W3006898322 cites W2941870488 @default.
- W3006898322 cites W2943582142 @default.
- W3006898322 cites W2976537818 @default.
- W3006898322 cites W2794523916 @default.
- W3006898322 doi "https://doi.org/10.1002/jbm.b.34591" @default.
- W3006898322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7383566" @default.
- W3006898322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32096606" @default.
- W3006898322 hasPublicationYear "2020" @default.
- W3006898322 type Work @default.
- W3006898322 sameAs 3006898322 @default.
- W3006898322 citedByCount "6" @default.
- W3006898322 countsByYear W30068983222020 @default.
- W3006898322 countsByYear W30068983222021 @default.
- W3006898322 countsByYear W30068983222023 @default.
- W3006898322 crossrefType "journal-article" @default.
- W3006898322 hasAuthorship W3006898322A5006755143 @default.
- W3006898322 hasAuthorship W3006898322A5032773909 @default.
- W3006898322 hasAuthorship W3006898322A5036318725 @default.
- W3006898322 hasAuthorship W3006898322A5048952889 @default.
- W3006898322 hasAuthorship W3006898322A5052636469 @default.
- W3006898322 hasAuthorship W3006898322A5053969245 @default.
- W3006898322 hasAuthorship W3006898322A5082918256 @default.
- W3006898322 hasAuthorship W3006898322A5086569305 @default.
- W3006898322 hasBestOaLocation W30068983221 @default.
- W3006898322 hasConcept C118131993 @default.
- W3006898322 hasConcept C136229726 @default.
- W3006898322 hasConcept C151166631 @default.
- W3006898322 hasConcept C159985019 @default.
- W3006898322 hasConcept C185592680 @default.
- W3006898322 hasConcept C189165786 @default.
- W3006898322 hasConcept C191897082 @default.
- W3006898322 hasConcept C192562407 @default.
- W3006898322 hasConcept C202751555 @default.
- W3006898322 hasConcept C2777230088 @default.
- W3006898322 hasConcept C2780381497 @default.
- W3006898322 hasConcept C55493867 @default.
- W3006898322 hasConcept C62478195 @default.
- W3006898322 hasConcept C71924100 @default.
- W3006898322 hasConcept C84416704 @default.
- W3006898322 hasConcept C85789140 @default.
- W3006898322 hasConcept C86803240 @default.