Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006906232> ?p ?o ?g. }
- W3006906232 abstract "Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥ 60 years who received breast cancer surgery between April 2013 and December 2017 in Shanghai Ruijin Hospital were retrospectively enrolled. Clinical and pathological features, MDT recommendations, administration of adjuvant treatment, cardiotoxicity, and disease outcome information were reviewed and analyzed. Results: A total of 222 older HER2-positive breast cancer patients were included and recommended to receive adjuvant chemotherapy plus trastuzumab therapy. Paclitaxel plus trastuzumab (PH, 41/222, 18.5%), docetaxel plus carboplatin and trastuzumab (TCH, 62/222, 27.9%), and antharcyclines plus cyclophosphamide followed by taxanes and trastuzumab (AC-TH, 119/222, 53.6%) were the three main regimens. Patients with T1a-b (P<0.001), grade 1-2 (P=0.008), node-negative (P<0.001), stage I (P<0.001), low Ki-67 level (P<0.001) disease, with cardiovascular comorbidities (P=0.011), and aged ≥ 70 years (P<0.001) were more likely to be recommended to PH regimen. Among the 178 patients who finally received adjuvant chemotherapy plus one-year trastuzumab treatment, only four patients (4/117, 3.4%) were recorded to have asymptomatic LVEF declining ≥ 10% but remaining ≥ 50% within one-year trastuzumab treatment. Conclusions: Clinical factors, including age, tumor size, node status, and cardiovascular comorbidity influenced the recommendation of trastuzumab with chemotherapy for older HER2-positive breast cancer patients. Low risk older HER2-positive breast cancer patients treated with PH had favorable outcome and good cardiac safety, which needed further clinical validation." @default.
- W3006906232 created "2020-03-06" @default.
- W3006906232 creator A5003031953 @default.
- W3006906232 creator A5008609549 @default.
- W3006906232 creator A5008911291 @default.
- W3006906232 creator A5020219997 @default.
- W3006906232 creator A5039212509 @default.
- W3006906232 creator A5051016025 @default.
- W3006906232 creator A5066927624 @default.
- W3006906232 creator A5068304714 @default.
- W3006906232 creator A5072445958 @default.
- W3006906232 creator A5074447759 @default.
- W3006906232 date "2020-01-01" @default.
- W3006906232 modified "2023-09-27" @default.
- W3006906232 title "Factors Influencing Adjuvant Chemotherapy and Trastuzumab Choice in Older Human Epidermal Growth Factor Receptor 2-positive Breast Cancer Patients" @default.
- W3006906232 cites W1919048041 @default.
- W3006906232 cites W1925211454 @default.
- W3006906232 cites W1991697331 @default.
- W3006906232 cites W1996778928 @default.
- W3006906232 cites W2037013151 @default.
- W3006906232 cites W2040935952 @default.
- W3006906232 cites W2058586633 @default.
- W3006906232 cites W2081105116 @default.
- W3006906232 cites W2095156669 @default.
- W3006906232 cites W2095633632 @default.
- W3006906232 cites W2097541112 @default.
- W3006906232 cites W2098775844 @default.
- W3006906232 cites W2108410343 @default.
- W3006906232 cites W2109103799 @default.
- W3006906232 cites W2109529837 @default.
- W3006906232 cites W2113450161 @default.
- W3006906232 cites W2141393790 @default.
- W3006906232 cites W2146384083 @default.
- W3006906232 cites W2146690654 @default.
- W3006906232 cites W2149908785 @default.
- W3006906232 cites W2152121934 @default.
- W3006906232 cites W2154221980 @default.
- W3006906232 cites W2169515690 @default.
- W3006906232 cites W2226378560 @default.
- W3006906232 cites W2318605753 @default.
- W3006906232 cites W2340601076 @default.
- W3006906232 cites W2479836145 @default.
- W3006906232 cites W2738336818 @default.
- W3006906232 doi "https://doi.org/10.7150/jca.39509" @default.
- W3006906232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7066021" @default.
- W3006906232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32201530" @default.
- W3006906232 hasPublicationYear "2020" @default.
- W3006906232 type Work @default.
- W3006906232 sameAs 3006906232 @default.
- W3006906232 citedByCount "0" @default.
- W3006906232 crossrefType "journal-article" @default.
- W3006906232 hasAuthorship W3006906232A5003031953 @default.
- W3006906232 hasAuthorship W3006906232A5008609549 @default.
- W3006906232 hasAuthorship W3006906232A5008911291 @default.
- W3006906232 hasAuthorship W3006906232A5020219997 @default.
- W3006906232 hasAuthorship W3006906232A5039212509 @default.
- W3006906232 hasAuthorship W3006906232A5051016025 @default.
- W3006906232 hasAuthorship W3006906232A5066927624 @default.
- W3006906232 hasAuthorship W3006906232A5068304714 @default.
- W3006906232 hasAuthorship W3006906232A5072445958 @default.
- W3006906232 hasAuthorship W3006906232A5074447759 @default.
- W3006906232 hasBestOaLocation W30069062321 @default.
- W3006906232 hasConcept C121608353 @default.
- W3006906232 hasConcept C126322002 @default.
- W3006906232 hasConcept C143998085 @default.
- W3006906232 hasConcept C2776694085 @default.
- W3006906232 hasConcept C2777863537 @default.
- W3006906232 hasConcept C2778239845 @default.
- W3006906232 hasConcept C2779786085 @default.
- W3006906232 hasConcept C2781190966 @default.
- W3006906232 hasConcept C2781413609 @default.
- W3006906232 hasConcept C2781451048 @default.
- W3006906232 hasConcept C530470458 @default.
- W3006906232 hasConcept C71924100 @default.
- W3006906232 hasConceptScore W3006906232C121608353 @default.
- W3006906232 hasConceptScore W3006906232C126322002 @default.
- W3006906232 hasConceptScore W3006906232C143998085 @default.
- W3006906232 hasConceptScore W3006906232C2776694085 @default.
- W3006906232 hasConceptScore W3006906232C2777863537 @default.
- W3006906232 hasConceptScore W3006906232C2778239845 @default.
- W3006906232 hasConceptScore W3006906232C2779786085 @default.
- W3006906232 hasConceptScore W3006906232C2781190966 @default.
- W3006906232 hasConceptScore W3006906232C2781413609 @default.
- W3006906232 hasConceptScore W3006906232C2781451048 @default.
- W3006906232 hasConceptScore W3006906232C530470458 @default.
- W3006906232 hasConceptScore W3006906232C71924100 @default.
- W3006906232 hasLocation W30069062321 @default.
- W3006906232 hasLocation W30069062322 @default.
- W3006906232 hasLocation W30069062323 @default.
- W3006906232 hasLocation W30069062324 @default.
- W3006906232 hasOpenAccess W3006906232 @default.
- W3006906232 hasPrimaryLocation W30069062321 @default.
- W3006906232 hasRelatedWork W1967391695 @default.
- W3006906232 hasRelatedWork W2277576025 @default.
- W3006906232 hasRelatedWork W2305906960 @default.
- W3006906232 hasRelatedWork W2533732361 @default.
- W3006906232 hasRelatedWork W2540085961 @default.
- W3006906232 hasRelatedWork W2781041469 @default.
- W3006906232 hasRelatedWork W2980453143 @default.
- W3006906232 hasRelatedWork W3033955709 @default.