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- W3006949083 abstract "Abstract Although cellular therapies for cancer have only recently burst onto the clinical scene, the underpinnings of these new therapeutics originate in three initially separate fields stretching back over the past 100 years. The ability of immune cells to recognise cancer cells and kill them was first discovered in the early 1900s, and, largely through bone marrow transplant, was leveraged therapeutically by adoptive cell transfer. More recently, the observations of how T cells activate in response to an antigen and form a broader immune response allowed physician-scientists to engineer immune cells to recognise specific targets of interest using chimeric antigen receptors (CARs). In parallel, gene transfer technology was developed by groups studying retroviruses, who ultimately overcame numerous safety and scalability challenges to generate lenti- and retroviral vectors capable of stably and safely transferring genes into primary human immune cells. In this chapter, we chronicle the origins of these fields and their convergence leading to the first clinically successful CAR-T cell therapies. Looking towards the future, we conclude by describing some of the challenges awaiting this entirely new biomedical frontier of cellular therapeutics." @default.
- W3006949083 created "2020-03-06" @default.
- W3006949083 creator A5001435038 @default.
- W3006949083 creator A5086683313 @default.
- W3006949083 date "2020-01-01" @default.
- W3006949083 modified "2023-09-26" @default.
- W3006949083 title "T Cell Engineering and the Rise of CAR-T Cell Therapies" @default.
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