Matches in SemOpenAlex for { <https://semopenalex.org/work/W3006969151> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3006969151 abstract "Recently, LSD1 is considered as a possible therapeutic mark for ovarian epithelial cancer (OEC). Though, the underlying molecular mechanism by which LSD1 endorses the oncogenesis of OEC has not been fully understood. Here, we revealed that overexpression of LSD1 downregulated Forkhead box O 3a (FOXO3a), while knockdown or pharmacological inhibition of LSD1 upregulated FOXO3a expression. Specifically, LSD1 interacted with demethylated FOXO3a. The LSD1-demethylated FOXO3a degraded via an ubiquitin-proteasome pathway. Biologically, LSD1 destabilized FOXO3a to abrogate its functions in the suppression of soft agar colony and cell proliferation formation in HO8910 ovarian cancer cells. Knockdown of FOXO3a rescued the restricted cell proliferation by LSD1 downregulation. As a whole, our study clarifies a way in ovarian cancer cell growth through the negative regulation of FOXO3a by LSD1." @default.
- W3006969151 created "2020-03-06" @default.
- W3006969151 creator A5030352815 @default.
- W3006969151 creator A5046881277 @default.
- W3006969151 creator A5052480181 @default.
- W3006969151 creator A5052494849 @default.
- W3006969151 creator A5054103314 @default.
- W3006969151 creator A5063481044 @default.
- W3006969151 creator A5073658864 @default.
- W3006969151 creator A5079565555 @default.
- W3006969151 creator A5086883094 @default.
- W3006969151 creator A5090945343 @default.
- W3006969151 date "2020-04-01" @default.
- W3006969151 modified "2023-09-24" @default.
- W3006969151 title "Lysine-specific demethylase 1 (LSD1) promotes ovarian cancer cell progression by Forkhead box O 3a (FOXO3a) inhibition" @default.
- W3006969151 doi "https://doi.org/10.1166/mex.2020.1674" @default.
- W3006969151 hasPublicationYear "2020" @default.
- W3006969151 type Work @default.
- W3006969151 sameAs 3006969151 @default.
- W3006969151 citedByCount "2" @default.
- W3006969151 countsByYear W30069691512020 @default.
- W3006969151 crossrefType "journal-article" @default.
- W3006969151 hasAuthorship W3006969151A5030352815 @default.
- W3006969151 hasAuthorship W3006969151A5046881277 @default.
- W3006969151 hasAuthorship W3006969151A5052480181 @default.
- W3006969151 hasAuthorship W3006969151A5052494849 @default.
- W3006969151 hasAuthorship W3006969151A5054103314 @default.
- W3006969151 hasAuthorship W3006969151A5063481044 @default.
- W3006969151 hasAuthorship W3006969151A5073658864 @default.
- W3006969151 hasAuthorship W3006969151A5079565555 @default.
- W3006969151 hasAuthorship W3006969151A5086883094 @default.
- W3006969151 hasAuthorship W3006969151A5090945343 @default.
- W3006969151 hasConcept C104317684 @default.
- W3006969151 hasConcept C121608353 @default.
- W3006969151 hasConcept C127561419 @default.
- W3006969151 hasConcept C1491633281 @default.
- W3006969151 hasConcept C170240278 @default.
- W3006969151 hasConcept C173396325 @default.
- W3006969151 hasConcept C2780427987 @default.
- W3006969151 hasConcept C2781364455 @default.
- W3006969151 hasConcept C41091548 @default.
- W3006969151 hasConcept C502942594 @default.
- W3006969151 hasConcept C54355233 @default.
- W3006969151 hasConcept C55493867 @default.
- W3006969151 hasConcept C555283112 @default.
- W3006969151 hasConcept C62112901 @default.
- W3006969151 hasConcept C81885089 @default.
- W3006969151 hasConcept C86803240 @default.
- W3006969151 hasConcept C95444343 @default.
- W3006969151 hasConceptScore W3006969151C104317684 @default.
- W3006969151 hasConceptScore W3006969151C121608353 @default.
- W3006969151 hasConceptScore W3006969151C127561419 @default.
- W3006969151 hasConceptScore W3006969151C1491633281 @default.
- W3006969151 hasConceptScore W3006969151C170240278 @default.
- W3006969151 hasConceptScore W3006969151C173396325 @default.
- W3006969151 hasConceptScore W3006969151C2780427987 @default.
- W3006969151 hasConceptScore W3006969151C2781364455 @default.
- W3006969151 hasConceptScore W3006969151C41091548 @default.
- W3006969151 hasConceptScore W3006969151C502942594 @default.
- W3006969151 hasConceptScore W3006969151C54355233 @default.
- W3006969151 hasConceptScore W3006969151C55493867 @default.
- W3006969151 hasConceptScore W3006969151C555283112 @default.
- W3006969151 hasConceptScore W3006969151C62112901 @default.
- W3006969151 hasConceptScore W3006969151C81885089 @default.
- W3006969151 hasConceptScore W3006969151C86803240 @default.
- W3006969151 hasConceptScore W3006969151C95444343 @default.
- W3006969151 hasLocation W30069691511 @default.
- W3006969151 hasOpenAccess W3006969151 @default.
- W3006969151 hasPrimaryLocation W30069691511 @default.
- W3006969151 hasRelatedWork W14024959 @default.
- W3006969151 hasRelatedWork W22642325 @default.
- W3006969151 hasRelatedWork W2880624 @default.
- W3006969151 hasRelatedWork W28993194 @default.
- W3006969151 hasRelatedWork W5363639 @default.
- W3006969151 hasRelatedWork W6320432 @default.
- W3006969151 hasRelatedWork W8036688 @default.
- W3006969151 hasRelatedWork W974582 @default.
- W3006969151 hasRelatedWork W21281701 @default.
- W3006969151 hasRelatedWork W6893594 @default.
- W3006969151 isParatext "false" @default.
- W3006969151 isRetracted "false" @default.
- W3006969151 magId "3006969151" @default.
- W3006969151 workType "article" @default.