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• W3007000503 abstract "Abstract Background: Mesenchymal stem/stromal cells (MSCs) from the decidua basalis (DBMSCs) of the human placenta have important functions that make them potential candidates for cellular therapy. Previously, we showed that DBMSC functions do not change significantly in a high oxidative stress environment, which was induced by hydrogen peroxide (H 2 O 2 ) and immune cells. Here, we studied the consequences of glucose, another oxidative stress inducer, on the phenotypic and functional changes in DBMSCs. Methods: DBMSCs were exposed to a high level of glucose, and its effect on DBMSC phenotypic and functional properties was determined. DBMSC expression of oxidative stress and immune molecules after exposure to glucose were also identified. Results: Conditioning of DBMSCs with glucose improved their adhesion and invasion. Glucose also increased DBMSC expression of genes with survival, proliferation, migration, invasion, anti-inflammatory, anti-chemoattractant and antimicrobial properties. In addition, DBMSC expression of B7H4, an inhibitor of T cell proliferation was also enhanced by glucose. Interestingly, glucose modulated DBMSC expression of genes involved in insulin secretion and prevention of diabetes. Conclusion: These data show the potentially beneficial effects of glucose on DBMSC functions. Preconditioning of DBMSCs with glucose may therefore be a rational strategy for increasing their therapeutic potential by enhancing their engraftment efficiency. In addition, glucose may program DBMSCs into insulin producing cells with ability to counteract inflammation and infection associated with diabetes. However, future in vitro and in vivo studies are essential to investigate the findings of this study further." @default.
• W3007000503 created "2020-03-06" @default.
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• W3007000503 date "2020-02-19" @default.
• W3007000503 modified "2023-10-02" @default.
• W3007000503 title "Preconditioning of Human Decidua Basalis Mesenchymal Stem/Stromal Cells with Glucose Increased Their Engraftment and Anti-diabetic Properties" @default.
• W3007000503 cites W11598776 @default.
• W3007000503 cites W1600180689 @default.
• W3007000503 cites W1835920973 @default.
• W3007000503 cites W1963619309 @default.
• W3007000503 cites W1973794493 @default.
• W3007000503 cites W1976004386 @default.
• W3007000503 cites W1979281993 @default.
• W3007000503 cites W1981712836 @default.
• W3007000503 cites W1981740916 @default.
• W3007000503 cites W1983213673 @default.
• W3007000503 cites W1995427091 @default.
• W3007000503 cites W1997241120 @default.
• W3007000503 cites W2000664994 @default.
• W3007000503 cites W2001582495 @default.
• W3007000503 cites W2006913911 @default.
• W3007000503 cites W2009554048 @default.
• W3007000503 cites W2019852638 @default.
• W3007000503 cites W2022765080 @default.
• W3007000503 cites W2035991594 @default.
• W3007000503 cites W2037954427 @default.
• W3007000503 cites W2042696326 @default.
• W3007000503 cites W2046692619 @default.
• W3007000503 cites W2051203706 @default.
• W3007000503 cites W2058819429 @default.
• W3007000503 cites W2069760818 @default.
• W3007000503 cites W2078047202 @default.
• W3007000503 cites W2085128107 @default.
• W3007000503 cites W2091194381 @default.
• W3007000503 cites W2091993254 @default.
• W3007000503 cites W2093761649 @default.
• W3007000503 cites W2099343588 @default.
• W3007000503 cites W2102960454 @default.
• W3007000503 cites W2105731956 @default.
• W3007000503 cites W2109069544 @default.
• W3007000503 cites W2117692196 @default.
• W3007000503 cites W2117905694 @default.
• W3007000503 cites W2124369185 @default.
• W3007000503 cites W2124419959 @default.
• W3007000503 cites W2128407235 @default.
• W3007000503 cites W2135693542 @default.
• W3007000503 cites W2139113799 @default.
• W3007000503 cites W2142707077 @default.
• W3007000503 cites W2146070804 @default.
• W3007000503 cites W2149292816 @default.
• W3007000503 cites W2156855881 @default.
• W3007000503 cites W2158106881 @default.
• W3007000503 cites W2273624704 @default.
• W3007000503 cites W2280938069 @default.
• W3007000503 cites W2317679593 @default.
• W3007000503 cites W2328437933 @default.
• W3007000503 cites W2335354937 @default.
• W3007000503 cites W2336133984 @default.
• W3007000503 cites W2340559944 @default.
• W3007000503 cites W2415032283 @default.
• W3007000503 cites W2468402352 @default.
• W3007000503 cites W2517871167 @default.
• W3007000503 cites W2547195251 @default.
• W3007000503 cites W2589550384 @default.
• W3007000503 cites W2604494781 @default.
• W3007000503 cites W2607335556 @default.
• W3007000503 cites W2610191841 @default.
• W3007000503 cites W2614191794 @default.
• W3007000503 cites W2615669773 @default.
• W3007000503 cites W2725358262 @default.
• W3007000503 cites W2729988698 @default.
• W3007000503 cites W2747485667 @default.
• W3007000503 cites W2762403983 @default.
• W3007000503 cites W2790095993 @default.
• W3007000503 cites W2792748704 @default.
• W3007000503 cites W2800719346 @default.
• W3007000503 cites W2802167664 @default.
• W3007000503 cites W2803978722 @default.
• W3007000503 cites W2892127028 @default.
• W3007000503 cites W2898513561 @default.
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• W3007000503 doi "https://doi.org/10.1007/s13770-020-00239-7" @default.
• W3007000503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7260300" @default.
• W3007000503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32363480" @default.
• W3007000503 hasPublicationYear "2020" @default.
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