FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007002738> ?p ?o ?g. }

• W3007002738 endingPage "348" @default.
• W3007002738 startingPage "337" @default.
• W3007002738 abstract "Increased level of an inflammation-responsive transcription factor called serum amyloid A-activating factor (SAF-1) has been linked to the pathogenesis in human breast cancer. SAF-1 is found to promote vascular endothelial growth factor (VEGF) expression in breast carcinoma cells and boost angiogenesis. In an effort to develop a cellular mechanism to control VEGF expression, we sought to limit SAF-1 activity in breast cancer cells. We report here several targets within the SAF-1 mRNA for binding of microRNA-125b (miR-125b) and we show that VEGF expression is reduced in breast cancer cells when SAF-1 level is reduced with the microRNA action. Within the 3' un-translated region (UTR) of SAF-1 transcript, we have identified four highly conserved miR-125b responsive elements. We show that these miR-125b binding sites mediate repression of SAF-1 by miR-125b. Ectopic expression of miR-125b in nonmetastatic and metastatic breast cancer cells repressed SAF-1-mediated activity on VEGF promoter function and inhibited cancer cell migration and invasion potentials in vitro. Together, these results suggest that termination of SAF-1 function by miR-125b could be developed as a potential anti-VEGF and anti-angiogenic agent, which has high clinical relevance." @default.
• W3007002738 created "2020-03-06" @default.
• W3007002738 creator A5020111511 @default.
• W3007002738 creator A5023928408 @default.
• W3007002738 date "2019-07-02" @default.
• W3007002738 modified "2023-10-13" @default.
• W3007002738 title "Suppression of vascular endothelial growth factor expression in breast cancer cells by microRNA-125b-mediated attenuation of serum amyloid A activating factor-1 level" @default.
• W3007002738 cites W144423133 @default.
• W3007002738 cites W1521589960 @default.
• W3007002738 cites W1648301895 @default.
• W3007002738 cites W1985712533 @default.
• W3007002738 cites W1985821841 @default.
• W3007002738 cites W1994061059 @default.
• W3007002738 cites W2004163835 @default.
• W3007002738 cites W2018532884 @default.
• W3007002738 cites W2019129907 @default.
• W3007002738 cites W2022979064 @default.
• W3007002738 cites W2030888171 @default.
• W3007002738 cites W2035068715 @default.
• W3007002738 cites W2042040883 @default.
• W3007002738 cites W2045228008 @default.
• W3007002738 cites W2048547076 @default.
• W3007002738 cites W2054223945 @default.
• W3007002738 cites W2064360454 @default.
• W3007002738 cites W2067768430 @default.
• W3007002738 cites W2074584135 @default.
• W3007002738 cites W2081100361 @default.
• W3007002738 cites W2083731794 @default.
• W3007002738 cites W2084675979 @default.
• W3007002738 cites W2087411126 @default.
• W3007002738 cites W2087523741 @default.
• W3007002738 cites W2093530104 @default.
• W3007002738 cites W2097382995 @default.
• W3007002738 cites W2101882577 @default.
• W3007002738 cites W2105053096 @default.
• W3007002738 cites W2109213714 @default.
• W3007002738 cites W2118166009 @default.
• W3007002738 cites W2124007301 @default.
• W3007002738 cites W2125293265 @default.
• W3007002738 cites W2130423812 @default.
• W3007002738 cites W2135836598 @default.
• W3007002738 cites W2135994545 @default.
• W3007002738 cites W2142221925 @default.
• W3007002738 cites W2144419407 @default.
• W3007002738 cites W2158556487 @default.
• W3007002738 cites W2159875482 @default.
• W3007002738 cites W2163021747 @default.
• W3007002738 cites W2163447682 @default.
• W3007002738 cites W2167052418 @default.
• W3007002738 cites W2168205469 @default.
• W3007002738 cites W2168523929 @default.
• W3007002738 cites W2171641698 @default.
• W3007002738 cites W2699220065 @default.
• W3007002738 cites W4235333461 @default.
• W3007002738 doi "https://doi.org/10.18632/oncoscience.483" @default.
• W3007002738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650169" @default.
• W3007002738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31360737" @default.
• W3007002738 hasPublicationYear "2019" @default.
• W3007002738 type Work @default.
• W3007002738 sameAs 3007002738 @default.
• W3007002738 citedByCount "4" @default.
• W3007002738 countsByYear W30070027382020 @default.
• W3007002738 countsByYear W30070027382022 @default.
• W3007002738 countsByYear W30070027382023 @default.
• W3007002738 crossrefType "journal-article" @default.
• W3007002738 hasAuthorship W3007002738A5020111511 @default.
• W3007002738 hasAuthorship W3007002738A5023928408 @default.
• W3007002738 hasBestOaLocation W30070027381 @default.
• W3007002738 hasConcept C104317684 @default.
• W3007002738 hasConcept C121608353 @default.
• W3007002738 hasConcept C126322002 @default.
• W3007002738 hasConcept C134018914 @default.
• W3007002738 hasConcept C145059251 @default.
• W3007002738 hasConcept C146285616 @default.
• W3007002738 hasConcept C167734588 @default.
• W3007002738 hasConcept C2777025900 @default.
• W3007002738 hasConcept C2780394083 @default.
• W3007002738 hasConcept C502942594 @default.
• W3007002738 hasConcept C530470458 @default.
• W3007002738 hasConcept C54355233 @default.
• W3007002738 hasConcept C55493867 @default.
• W3007002738 hasConcept C71924100 @default.
• W3007002738 hasConcept C81885089 @default.
• W3007002738 hasConcept C86803240 @default.
• W3007002738 hasConcept C97037327 @default.
• W3007002738 hasConceptScore W3007002738C104317684 @default.
• W3007002738 hasConceptScore W3007002738C121608353 @default.
• W3007002738 hasConceptScore W3007002738C126322002 @default.
• W3007002738 hasConceptScore W3007002738C134018914 @default.
• W3007002738 hasConceptScore W3007002738C145059251 @default.
• W3007002738 hasConceptScore W3007002738C146285616 @default.
• W3007002738 hasConceptScore W3007002738C167734588 @default.
• W3007002738 hasConceptScore W3007002738C2777025900 @default.
• W3007002738 hasConceptScore W3007002738C2780394083 @default.
• W3007002738 hasConceptScore W3007002738C502942594 @default.
• W3007002738 hasConceptScore W3007002738C530470458 @default.
• W3007002738 hasConceptScore W3007002738C54355233 @default.
• W3007002738 hasConceptScore W3007002738C55493867 @default.

• next