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• W3007029695 abstract "Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. The synthesized compounds are characterized by spectroscopic techniques such as FT-IR, HRMS and NMR. These compounds are investigated for cytotoxicity on different cancer cell lines and heparanase inhibitory activity. Most of them showed moderate heparanase inhibitory activity and good cytotoxicity." @default.
• W3007029695 created "2020-03-06" @default.
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• W3007029695 date "2020-06-09" @default.
• W3007029695 modified "2023-09-26" @default.
• W3007029695 title "Synthesis, Cytotoxic and Heparanase Inhibition Studies of 5-oxo-1-arylpyrrolidine-3- carboxamides of Hydrazides and 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol" @default.
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• W3007029695 doi "https://doi.org/10.2174/1570179417666200225123329" @default.
• W3007029695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32096746" @default.
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