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- W3007029763 abstract "Abstract Temporal and spatial control of mRNA translation has emerged as a major mechanism for promoting diverse biological processes. However, the molecular nature of temporal control of translation remains unclear. In oocytes, many mRNAs are deposited as a translationally repressed form and are translated at appropriate timings to promote the progression of meiosis and development. Here, we show that changes in structures and states of the RNA-binding protein Pumilio1 regulate the translation of target mRNAs and progression of oocyte maturation. Pumilio1 was shown to bind to Mad2 and Cyclin B1 mRNAs, assemble highly clustered solid-like aggregates, and surround Mad2 and Cyclin B1 RNA granules in mouse oocytes. These Pumilio1 aggregates were dissolved by phosphorylation prior to the translational activation of target mRNAs. Stabilization of Pumilio1 aggregates prevented the translational activation of target mRNAs and oocyte maturation. Together, our results provide an aggregation-dissolution model for the temporal and spatial control of translation." @default.
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- W3007029763 date "2020-02-25" @default.
- W3007029763 modified "2023-10-11" @default.
- W3007029763 title "Changes in subcellular structures and states of Pumilio1 regulate the translation of target<i>Mad2</i>and<i>Cyclin B1</i>mRNAs" @default.
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- W3007029763 doi "https://doi.org/10.1101/2020.02.25.964668" @default.
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