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- W30070312 abstract "This chapter discusses hypothyroidism and studies relating hypothyroidism to atherosclerosis. It also presents dextrothyroxine studies. Thyroxine acts on a large number of enzymes such as succinoxidase, creatine phosphokinase, 6-glucose phosphate hydrogenase, and many others, particularly in organs involved in atherosclerotic myocardial disease, that is, liver, kidney, heart, and skeletal muscles. Hypothyroidism is the subnormal condition of biochemical processes dependent on thyroxine and/or triiodothyronine. The lack of frequency of total athyreosis, which constitutes only 5% of all cases of hypothyroidism in a population, is responsible for the lack of diagnostic investigation of all patients with hypercholesterolemia, in regard to hypothyroidism. The state of hypothyroidism cannot be proved by the measurement of the concentration of thyroid hormone in the circulating blood. If atherosclerosis with cardiac dysfunction is present or anticipated because of associated hypercholesteremic lipoprotein disease, sodium D-thyroxine can be the drug of choice. Thyroid deficits do not exist if the usual indices, such as serum protein-bound iodine, 131I trapping, and protein-bound 131I conversion ratios are normal." @default.
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- W30070312 date "1978-01-01" @default.
- W30070312 modified "2023-10-18" @default.
- W30070312 title "Atherosclerosis, Hypothyroidism, and Thyroid Hormone Therapy" @default.
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- W30070312 doi "https://doi.org/10.1016/b978-0-12-024916-9.50013-5" @default.
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