FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3007056262> ?p ?o ?g. }

• W3007056262 endingPage "119164" @default.
• W3007056262 startingPage "119164" @default.
• W3007056262 abstract "Abstract Floating gastro-retentive delivery systems can prolong the gastric residence providing sustained drug release. In this study, we report on self-inflating effervescence-based electrospun nanofiber membranes embedding polyethylene oxide/sodium bicarbonate cast films. In this system, sodium bicarbonate results in an effervescence effect by creating carbon dioxide gas upon contacting an acidic gastric fluid, with the resulting gas bubbles being entrapped within the swollen network of nanofibers. Eudragit RL and RS polymers are utilized as a host material to manipulate release kinetics of incorporated drugs. Pramipexole, a common medication for chronic Parkinson’s disease (PD), is used as a model drug. Uniform and bead-free nanofibers with diameters of ~300 nm were obtained. Although floating nanofibers initially exhibited high water contact angles (WCA), water droplets were quickly absorbed into the surface and the WCA decreased to ~0° within 60 s. Floating lag time, total floating time, swelling properties and drug release profiles were investigated both in a simulated gastric fluid (pH 1.2 buffer solution) and in a simulated intestinal fluid (pH 6.8 buffer solution) at 37 °C. All floating nanofiber formulations began to float instantly with nearly zero floating lag time and did not sink into the solution even after 24 h. By comparison, the same formulations without sodium bicarbonate cast films could not maintain continuous floating beyond 15 min. The floating nanofiber pouches presented lower initial release of between 20 and 57 %, compared to that of non-floating nanofiber pouches (40–82% within 2 h). Clearly, floating nanofibers reduced the initial burst release and provided sustained drug release. This demonstrates the potential to result in ‘once-a-day’ oral introduction of drugs that normally must be taken frequently. Effervescence-based floating nanofibers present a novel and promising prototype delivery system for the drug delivery in the upper gastro-intestinal (GI) tract." @default.
• W3007056262 created "2020-03-06" @default.
• W3007056262 creator A5009848607 @default.
• W3007056262 creator A5076842560 @default.
• W3007056262 creator A5084041739 @default.
• W3007056262 date "2020-04-01" @default.
• W3007056262 modified "2023-09-29" @default.
• W3007056262 title "Self-inflating floating nanofiber membranes for controlled drug delivery" @default.
• W3007056262 cites W1974614583 @default.
• W3007056262 cites W1976558157 @default.
• W3007056262 cites W1976903082 @default.
• W3007056262 cites W1979604548 @default.
• W3007056262 cites W1979763877 @default.
• W3007056262 cites W1980041206 @default.
• W3007056262 cites W1981266770 @default.
• W3007056262 cites W1985958463 @default.
• W3007056262 cites W1995634417 @default.
• W3007056262 cites W1996823723 @default.
• W3007056262 cites W2012185697 @default.
• W3007056262 cites W2012297854 @default.
• W3007056262 cites W2018388329 @default.
• W3007056262 cites W2019618346 @default.
• W3007056262 cites W2029906991 @default.
• W3007056262 cites W2030635777 @default.
• W3007056262 cites W2031823368 @default.
• W3007056262 cites W2053551391 @default.
• W3007056262 cites W2072485809 @default.
• W3007056262 cites W2075139947 @default.
• W3007056262 cites W2078273899 @default.
• W3007056262 cites W2079140183 @default.
• W3007056262 cites W2081056194 @default.
• W3007056262 cites W2084870410 @default.
• W3007056262 cites W2092321786 @default.
• W3007056262 cites W2096232564 @default.
• W3007056262 cites W2120684240 @default.
• W3007056262 cites W2124933617 @default.
• W3007056262 cites W2148311266 @default.
• W3007056262 cites W2152745786 @default.
• W3007056262 cites W2158702719 @default.
• W3007056262 cites W2164119404 @default.
• W3007056262 cites W2178210816 @default.
• W3007056262 cites W2180034355 @default.
• W3007056262 cites W2283323577 @default.
• W3007056262 cites W2345335071 @default.
• W3007056262 cites W2409988041 @default.
• W3007056262 cites W2464012159 @default.
• W3007056262 cites W2470104756 @default.
• W3007056262 cites W2551058620 @default.
• W3007056262 cites W2564783893 @default.
• W3007056262 cites W2588285316 @default.
• W3007056262 cites W2593805300 @default.
• W3007056262 cites W2597365136 @default.
• W3007056262 cites W2597832334 @default.
• W3007056262 cites W2604731858 @default.
• W3007056262 cites W2606185657 @default.
• W3007056262 cites W2763716479 @default.
• W3007056262 cites W2767387691 @default.
• W3007056262 cites W2767637829 @default.
• W3007056262 cites W2773529415 @default.
• W3007056262 cites W2777557500 @default.
• W3007056262 cites W2793730002 @default.
• W3007056262 cites W2800158249 @default.
• W3007056262 cites W2887960646 @default.
• W3007056262 cites W2888203291 @default.
• W3007056262 cites W2891464502 @default.
• W3007056262 cites W2898172685 @default.
• W3007056262 cites W2929709643 @default.
• W3007056262 cites W2947774269 @default.
• W3007056262 cites W343878649 @default.
• W3007056262 doi "https://doi.org/10.1016/j.ijpharm.2020.119164" @default.
• W3007056262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32081796" @default.
• W3007056262 hasPublicationYear "2020" @default.
• W3007056262 type Work @default.
• W3007056262 sameAs 3007056262 @default.
• W3007056262 citedByCount "28" @default.
• W3007056262 countsByYear W30070562622020 @default.
• W3007056262 countsByYear W30070562622021 @default.
• W3007056262 countsByYear W30070562622022 @default.
• W3007056262 countsByYear W30070562622023 @default.
• W3007056262 crossrefType "journal-article" @default.
• W3007056262 hasAuthorship W3007056262A5009848607 @default.
• W3007056262 hasAuthorship W3007056262A5076842560 @default.
• W3007056262 hasAuthorship W3007056262A5084041739 @default.
• W3007056262 hasConcept C171250308 @default.
• W3007056262 hasConcept C185592680 @default.
• W3007056262 hasConcept C192562407 @default.
• W3007056262 hasConcept C2779820397 @default.
• W3007056262 hasConcept C2780035454 @default.
• W3007056262 hasConcept C41625074 @default.
• W3007056262 hasConcept C55493867 @default.
• W3007056262 hasConcept C71924100 @default.
• W3007056262 hasConcept C91129048 @default.
• W3007056262 hasConcept C98274493 @default.
• W3007056262 hasConceptScore W3007056262C171250308 @default.
• W3007056262 hasConceptScore W3007056262C185592680 @default.
• W3007056262 hasConceptScore W3007056262C192562407 @default.
• W3007056262 hasConceptScore W3007056262C2779820397 @default.
• W3007056262 hasConceptScore W3007056262C2780035454 @default.

• next