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- W3007084208 abstract "Previous studies before the introduction of C1-esterase inhibitor therapy demonstrate frequent emergency department (ED) visits. However, little is known about current patterns of care and abdominal imaging for HAE patients in the ED. We analyzed the 2015-2016 National Emergency Data Sample, a cross-sectional, representative sample of ED visits in the US. Multivariable logistic regression models invoking stepwise selection were constructed to determine associations of ED visits for HAE. Regression models adjusted for age, sex, and payer were constructed to assess odds of abdominal pain, radiologic imaging, and incidence of conditions requiring abdominal imaging. There were an estimated 7,073 ED visits with a primary HAE diagnosis between 2015-2016. Geometric mean and total costs of ED care for HAE patients during the two-year period were $3,598 and $55,842,163, respectively. In logistic regression models invoking stepwise selection, ED visits for HAE vs angioedema occurred more often during the autumn months (adjusted OR [aOR] [95% CI]: 1.39 [1.08-1.78]), but were inversely associated with older age (40-59 years: 0.49 [0.29-0.82], 60+ years: 0.24 [0.08-0.70]), lack of insurance (0.44 [0.30-0.66]), and weekend visit (0.82 [0.72-0.95]). ED visits for HAE vs angioedema had higher odds of abdominal pain diagnosis (aOR [95% CI]: 40.54 [25.09-65.50]), with ∼10 times higher odds of abdominal CT and x-ray imaging, without increased incidence of common pathologies that indicate need for abdominal imaging. One in 10 ED visits for HAE led to inpatient hospitalization. There is substantial financial burden of ED utilization among patients with HAE, with high rates of unnecessary abdominal imaging." @default.
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- W3007084208 date "2020-02-01" @default.
- W3007084208 modified "2023-09-28" @default.
- W3007084208 title "Burden of emergency department utilization for hereditary angioedema" @default.
- W3007084208 doi "https://doi.org/10.1016/j.jaci.2019.12.618" @default.
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